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Review on Structures of Pesticide Targets

Molecular targets play important roles in agrochemical discovery. Numerous pesticides target the key proteins in pathogens, insect, or plants. Investigating ligand-binding pockets and/or active sites in the proteins’ structures is usually the first step in designing new green pesticides. Thus, molec...

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Detalles Bibliográficos
Autores principales: Li, Xiangyang, Yang, Xueqing, Zheng, Xiaodong, Bai, Miao, Hu, Deyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582455/
https://www.ncbi.nlm.nih.gov/pubmed/32998191
http://dx.doi.org/10.3390/ijms21197144
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author Li, Xiangyang
Yang, Xueqing
Zheng, Xiaodong
Bai, Miao
Hu, Deyu
author_facet Li, Xiangyang
Yang, Xueqing
Zheng, Xiaodong
Bai, Miao
Hu, Deyu
author_sort Li, Xiangyang
collection PubMed
description Molecular targets play important roles in agrochemical discovery. Numerous pesticides target the key proteins in pathogens, insect, or plants. Investigating ligand-binding pockets and/or active sites in the proteins’ structures is usually the first step in designing new green pesticides. Thus, molecular target structures are extremely important for the discovery and development of such pesticides. In this manuscript, we present a review of the molecular target structures, including those of antiviral, fungicidal, bactericidal, insecticidal, herbicidal, and plant growth-regulator targets, currently used in agrochemical research. The data will be helpful in pesticide design and the discovery of new green pesticides.
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spelling pubmed-75824552020-10-29 Review on Structures of Pesticide Targets Li, Xiangyang Yang, Xueqing Zheng, Xiaodong Bai, Miao Hu, Deyu Int J Mol Sci Review Molecular targets play important roles in agrochemical discovery. Numerous pesticides target the key proteins in pathogens, insect, or plants. Investigating ligand-binding pockets and/or active sites in the proteins’ structures is usually the first step in designing new green pesticides. Thus, molecular target structures are extremely important for the discovery and development of such pesticides. In this manuscript, we present a review of the molecular target structures, including those of antiviral, fungicidal, bactericidal, insecticidal, herbicidal, and plant growth-regulator targets, currently used in agrochemical research. The data will be helpful in pesticide design and the discovery of new green pesticides. MDPI 2020-09-28 /pmc/articles/PMC7582455/ /pubmed/32998191 http://dx.doi.org/10.3390/ijms21197144 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Li, Xiangyang
Yang, Xueqing
Zheng, Xiaodong
Bai, Miao
Hu, Deyu
Review on Structures of Pesticide Targets
title Review on Structures of Pesticide Targets
title_full Review on Structures of Pesticide Targets
title_fullStr Review on Structures of Pesticide Targets
title_full_unstemmed Review on Structures of Pesticide Targets
title_short Review on Structures of Pesticide Targets
title_sort review on structures of pesticide targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582455/
https://www.ncbi.nlm.nih.gov/pubmed/32998191
http://dx.doi.org/10.3390/ijms21197144
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