Excess Protein O-GlcNAcylation Links Metabolic Derangements to Right Ventricular Dysfunction in Pulmonary Arterial Hypertension

The hexosamine biosynthetic pathway (HBP) converts glucose to uridine-diphosphate-N-acetylglucosamine, which, when added to serines or threonines, modulates protein function through protein O-GlcNAcylation. Glutamine-fructose-6-phosphate amidotransferase (GFAT) regulates HBP flux, and AMP-kinase pho...

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Detalles Bibliográficos
Autores principales: Prisco, Sasha Z., Rose, Lauren, Potus, Francois, Tian, Lian, Wu, Danchen, Hartweck, Lynn, Al-Qazazi, Ruaa, Neuber-Hess, Monica, Eklund, Megan, Hsu, Steven, Thenappan, Thenappan, Archer, Stephen L., Prins, Kurt W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582480/
https://www.ncbi.nlm.nih.gov/pubmed/33019763
http://dx.doi.org/10.3390/ijms21197278

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