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Redox Regulation of STAT1 and STAT3 Signaling
STAT1 and STAT3 are nuclear transcription factors that regulate genes involved in cell cycle, cell survival and immune response. The cross-talk between these signaling pathways determines how cells integrate the environmental signals received ultimately translating them in transcriptional regulation...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582491/ https://www.ncbi.nlm.nih.gov/pubmed/32987855 http://dx.doi.org/10.3390/ijms21197034 |
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author | Butturini, Elena Carcereri de Prati, Alessandra Mariotto, Sofia |
author_facet | Butturini, Elena Carcereri de Prati, Alessandra Mariotto, Sofia |
author_sort | Butturini, Elena |
collection | PubMed |
description | STAT1 and STAT3 are nuclear transcription factors that regulate genes involved in cell cycle, cell survival and immune response. The cross-talk between these signaling pathways determines how cells integrate the environmental signals received ultimately translating them in transcriptional regulation of specific sets of genes. Despite being activated downstream of common cytokine and growth factors, STAT1 and STAT3 play essentially antagonistic roles and the disruption of their balance directs cells from survival to apoptotic cell death or from inflammatory to anti-inflammatory responses. Different mechanisms are proposed to explain this yin-yang relationship. Considering the redox aspect of STATs proteins, this review attempts to summarize the current knowledge of redox regulation of STAT1 and STAT3 signaling focusing the attention on the post-translational modifications that affect their activity. |
format | Online Article Text |
id | pubmed-7582491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75824912020-10-29 Redox Regulation of STAT1 and STAT3 Signaling Butturini, Elena Carcereri de Prati, Alessandra Mariotto, Sofia Int J Mol Sci Review STAT1 and STAT3 are nuclear transcription factors that regulate genes involved in cell cycle, cell survival and immune response. The cross-talk between these signaling pathways determines how cells integrate the environmental signals received ultimately translating them in transcriptional regulation of specific sets of genes. Despite being activated downstream of common cytokine and growth factors, STAT1 and STAT3 play essentially antagonistic roles and the disruption of their balance directs cells from survival to apoptotic cell death or from inflammatory to anti-inflammatory responses. Different mechanisms are proposed to explain this yin-yang relationship. Considering the redox aspect of STATs proteins, this review attempts to summarize the current knowledge of redox regulation of STAT1 and STAT3 signaling focusing the attention on the post-translational modifications that affect their activity. MDPI 2020-09-24 /pmc/articles/PMC7582491/ /pubmed/32987855 http://dx.doi.org/10.3390/ijms21197034 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Butturini, Elena Carcereri de Prati, Alessandra Mariotto, Sofia Redox Regulation of STAT1 and STAT3 Signaling |
title | Redox Regulation of STAT1 and STAT3 Signaling |
title_full | Redox Regulation of STAT1 and STAT3 Signaling |
title_fullStr | Redox Regulation of STAT1 and STAT3 Signaling |
title_full_unstemmed | Redox Regulation of STAT1 and STAT3 Signaling |
title_short | Redox Regulation of STAT1 and STAT3 Signaling |
title_sort | redox regulation of stat1 and stat3 signaling |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582491/ https://www.ncbi.nlm.nih.gov/pubmed/32987855 http://dx.doi.org/10.3390/ijms21197034 |
work_keys_str_mv | AT butturinielena redoxregulationofstat1andstat3signaling AT carcereridepratialessandra redoxregulationofstat1andstat3signaling AT mariottosofia redoxregulationofstat1andstat3signaling |