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Redox Regulation of STAT1 and STAT3 Signaling

STAT1 and STAT3 are nuclear transcription factors that regulate genes involved in cell cycle, cell survival and immune response. The cross-talk between these signaling pathways determines how cells integrate the environmental signals received ultimately translating them in transcriptional regulation...

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Detalles Bibliográficos
Autores principales: Butturini, Elena, Carcereri de Prati, Alessandra, Mariotto, Sofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582491/
https://www.ncbi.nlm.nih.gov/pubmed/32987855
http://dx.doi.org/10.3390/ijms21197034
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author Butturini, Elena
Carcereri de Prati, Alessandra
Mariotto, Sofia
author_facet Butturini, Elena
Carcereri de Prati, Alessandra
Mariotto, Sofia
author_sort Butturini, Elena
collection PubMed
description STAT1 and STAT3 are nuclear transcription factors that regulate genes involved in cell cycle, cell survival and immune response. The cross-talk between these signaling pathways determines how cells integrate the environmental signals received ultimately translating them in transcriptional regulation of specific sets of genes. Despite being activated downstream of common cytokine and growth factors, STAT1 and STAT3 play essentially antagonistic roles and the disruption of their balance directs cells from survival to apoptotic cell death or from inflammatory to anti-inflammatory responses. Different mechanisms are proposed to explain this yin-yang relationship. Considering the redox aspect of STATs proteins, this review attempts to summarize the current knowledge of redox regulation of STAT1 and STAT3 signaling focusing the attention on the post-translational modifications that affect their activity.
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spelling pubmed-75824912020-10-29 Redox Regulation of STAT1 and STAT3 Signaling Butturini, Elena Carcereri de Prati, Alessandra Mariotto, Sofia Int J Mol Sci Review STAT1 and STAT3 are nuclear transcription factors that regulate genes involved in cell cycle, cell survival and immune response. The cross-talk between these signaling pathways determines how cells integrate the environmental signals received ultimately translating them in transcriptional regulation of specific sets of genes. Despite being activated downstream of common cytokine and growth factors, STAT1 and STAT3 play essentially antagonistic roles and the disruption of their balance directs cells from survival to apoptotic cell death or from inflammatory to anti-inflammatory responses. Different mechanisms are proposed to explain this yin-yang relationship. Considering the redox aspect of STATs proteins, this review attempts to summarize the current knowledge of redox regulation of STAT1 and STAT3 signaling focusing the attention on the post-translational modifications that affect their activity. MDPI 2020-09-24 /pmc/articles/PMC7582491/ /pubmed/32987855 http://dx.doi.org/10.3390/ijms21197034 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Butturini, Elena
Carcereri de Prati, Alessandra
Mariotto, Sofia
Redox Regulation of STAT1 and STAT3 Signaling
title Redox Regulation of STAT1 and STAT3 Signaling
title_full Redox Regulation of STAT1 and STAT3 Signaling
title_fullStr Redox Regulation of STAT1 and STAT3 Signaling
title_full_unstemmed Redox Regulation of STAT1 and STAT3 Signaling
title_short Redox Regulation of STAT1 and STAT3 Signaling
title_sort redox regulation of stat1 and stat3 signaling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582491/
https://www.ncbi.nlm.nih.gov/pubmed/32987855
http://dx.doi.org/10.3390/ijms21197034
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