Cargando…

The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme

A series of berberine and tetrahydroberberine sulfonate derivatives were prepared and tested against the tyrosyl-DNA phosphodiesterase 1 (Tdp1) DNA-repair enzyme. The berberine derivatives inhibit the Tdp1 enzyme in the low micromolar range; this is the first reported berberine based Tdp1 inhibitor....

Descripción completa

Detalles Bibliográficos
Autores principales:	Gladkova, Elizaveta D., Nechepurenko, Ivan V., Bredikhin, Roman A., Chepanova, Arina A., Zakharenko, Alexandra L., Luzina, Olga A., Ilina, Ekaterina S., Dyrkheeva, Nadezhda S., Mamontova, Evgeniya M., Anarbaev, Rashid O., Reynisson, Jóhannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582571/ https://www.ncbi.nlm.nih.gov/pubmed/32998385 http://dx.doi.org/10.3390/ijms21197162

Ejemplares similares

Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1
por: Zakharenko, Alexandra L., et al.
Publicado: (2023)

New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2
por: Salomatina, Oksana V., et al.
Publicado: (2021)

Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors
por: Gladkova, Elizaveta D., et al.
Publicado: (2021)

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition
por: Dyrkheeva, Nadezhda S., et al.
Publicado: (2021)

New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan
por: Khomenko, Tatyana M., et al.
Publicado: (2023)

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold
por: Li-Zhulanov, Nikolai S., et al.
Publicado: (2018)

Influence of Tyrosyl-DNA Phosphodiesterase 1 Inhibitor on the Proapoptotic and Genotoxic Effects of Anticancer Agent Topotecan
por: Chepanova, A. A., et al.
Publicado: (2023)

Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy
por: Khomenko, Tatyana M., et al.
Publicado: (2019)

Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents
por: Zakharenko, Alexandra L., et al.
Publicado: (2023)

Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments
por: Munkuev, Aldar A., et al.
Publicado: (2021)

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors
por: Salomatina, Oksana V., et al.
Publicado: (2018)

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors
por: Filimonov, Aleksander S., et al.
Publicado: (2019)

Human Tyrosyl-DNA Phosphodiesterase 1 Possesses Transphosphooligonucleotidation Activity With Primary Alcohols
por: Dyrkheeva, Nadezhda, et al.
Publicado: (2020)

Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides
por: Zakharenko, Alexandra L., et al.
Publicado: (2020)

Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties
por: Ivankin, Dmitry I., et al.
Publicado: (2023)

Design, Synthesis, and Molecular Docking Study of New Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors Combining Resin Acids and Adamantane Moieties
por: Kovaleva, Kseniya, et al.
Publicado: (2021)

Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1
por: Il’ina, Irina V., et al.
Publicado: (2020)

New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1
por: Dyrkheeva, Nadezhda S., et al.
Publicado: (2021)

Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy
por: Komarova, Anastasia O., et al.
Publicado: (2018)

In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions
por: Dyrkheeva, Nadezhda S., et al.
Publicado: (2022)

Poly(ADP-ribose)polymerase 1 stimulates the AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1
por: Lebedeva, Natalia A., et al.
Publicado: (2015)

Structure Modeling of Human Tyrosyl-DNA Phosphodiesterase 1 and Screening for Its Inhibitors
por: Gushchina, I.V., et al.
Publicado: (2017)

Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites
por: Lebedeva, Natalia A., et al.
Publicado: (2012)

Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor
por: Dyrkheeva, Nadezhda S., et al.
Publicado: (2023)

Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan
por: Munkuev, Aldar A., et al.
Publicado: (2022)

Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site
por: Lebedeva, Natalia A., et al.
Publicado: (2021)

Mechanism of 5′ Topoisomerase II DNA adduct repair by mammalian Tyrosyl DNA phosphodiesterase 2 (Tdp2)
por: Schellenberg, Matthew J., et al.
Publicado: (2012)

The Lipophilic Purine Nucleoside—Tdp1 Inhibitor—Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo
por: Chernyshova, Irina A., et al.
Publicado: (2022)

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors
por: Walker, Sarah, et al.
Publicado: (2014)

Repair of topoisomerase 1–induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding
por: Shimizu, Naoto, et al.
Publicado: (2023)

Deficiency in 3′-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)
por: Zhou, Tong, et al.
Publicado: (2005)

The Tyrosyl-DNA Phosphodiesterase 1β (Tdp1β) Gene Discloses an Early Response to Abiotic Stresses
por: Sabatini, Maria Elisa, et al.
Publicado: (2017)

Plant TDP1 (Tyrosyl-DNA Phosphodiesterase 1): A Phylogenetic Perspective and Gene Expression Data Mining
por: Mutti, Giacomo, et al.
Publicado: (2020)

The Human Tyrosyl-DNA Phosphodiesterase 1 (hTdp1) Inhibitor NSC120686 as an Exploratory Tool to Investigate Plant Tdp1 Genes
por: Macovei, Anca, et al.
Publicado: (2018)

Tyrosyl-DNA phosphodiesterase 1 (TDP1) and SPRTN protease repair histone 3 and topoisomerase 1 DNA–protein crosslinks in vivo
por: Anticevic, Ivan, et al.
Publicado: (2023)

Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair
por: Huang, Shar-yin Naomi, et al.
Publicado: (2019)

Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification
por: Zhao, Xue Zhi, et al.
Publicado: (2023)

Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach
por: Volcho, Konstantin P., et al.
Publicado: (2023)

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1
por: Antony, Smitha, et al.
Publicado: (2007)

TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage
por: Zeng, Zhihong, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ck8ikd4ad4agulqjo5d28r8g9k