Two New Indole Alkaloids from Toad Venom of Bufo bufo gargarizans

Two new indole alkaloids, Bufotenidine B (2) and Bufocarboline A (6), along with seven known indole alkaloids (1, 3–5, and 7–9) and three organic acids (10–12), were isolated from the water extract of toad venom. The structures of the new alkaloids were elucidated by extensive spectroscopic methods....

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Detalles Bibliográficos
Autores principales: Chen, Yu-Lin, Dai, Ying-Hui, Wang, An-Dong, Zhou, Zi-Ying, Lei, Miao, Liu, Jiao, Lin, Bin, Xia, Ming-Yu, Wang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582642/
https://www.ncbi.nlm.nih.gov/pubmed/33019706
http://dx.doi.org/10.3390/molecules25194511
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author Chen, Yu-Lin
Dai, Ying-Hui
Wang, An-Dong
Zhou, Zi-Ying
Lei, Miao
Liu, Jiao
Lin, Bin
Xia, Ming-Yu
Wang, Dong
author_facet Chen, Yu-Lin
Dai, Ying-Hui
Wang, An-Dong
Zhou, Zi-Ying
Lei, Miao
Liu, Jiao
Lin, Bin
Xia, Ming-Yu
Wang, Dong
author_sort Chen, Yu-Lin
collection PubMed
description Two new indole alkaloids, Bufotenidine B (2) and Bufocarboline A (6), along with seven known indole alkaloids (1, 3–5, and 7–9) and three organic acids (10–12), were isolated from the water extract of toad venom. The structures of the new alkaloids were elucidated by extensive spectroscopic methods. The absolute configurations of 4, 6, and 8 were determined for the first time by electronic circular dichroism (ECD) calculations. The cytotoxic activity of all compounds was tested against human malignant melanoma cells A375 by the MTT method, and no antitumor activity was observed.
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spelling pubmed-75826422020-10-28 Two New Indole Alkaloids from Toad Venom of Bufo bufo gargarizans Chen, Yu-Lin Dai, Ying-Hui Wang, An-Dong Zhou, Zi-Ying Lei, Miao Liu, Jiao Lin, Bin Xia, Ming-Yu Wang, Dong Molecules Article Two new indole alkaloids, Bufotenidine B (2) and Bufocarboline A (6), along with seven known indole alkaloids (1, 3–5, and 7–9) and three organic acids (10–12), were isolated from the water extract of toad venom. The structures of the new alkaloids were elucidated by extensive spectroscopic methods. The absolute configurations of 4, 6, and 8 were determined for the first time by electronic circular dichroism (ECD) calculations. The cytotoxic activity of all compounds was tested against human malignant melanoma cells A375 by the MTT method, and no antitumor activity was observed. MDPI 2020-10-01 /pmc/articles/PMC7582642/ /pubmed/33019706 http://dx.doi.org/10.3390/molecules25194511 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Yu-Lin
Dai, Ying-Hui
Wang, An-Dong
Zhou, Zi-Ying
Lei, Miao
Liu, Jiao
Lin, Bin
Xia, Ming-Yu
Wang, Dong
Two New Indole Alkaloids from Toad Venom of Bufo bufo gargarizans
title Two New Indole Alkaloids from Toad Venom of Bufo bufo gargarizans
title_full Two New Indole Alkaloids from Toad Venom of Bufo bufo gargarizans
title_fullStr Two New Indole Alkaloids from Toad Venom of Bufo bufo gargarizans
title_full_unstemmed Two New Indole Alkaloids from Toad Venom of Bufo bufo gargarizans
title_short Two New Indole Alkaloids from Toad Venom of Bufo bufo gargarizans
title_sort two new indole alkaloids from toad venom of bufo bufo gargarizans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582642/
https://www.ncbi.nlm.nih.gov/pubmed/33019706
http://dx.doi.org/10.3390/molecules25194511
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