Mechanisms of Deamidation of Asparagine Residues and Effects of Main-Chain Conformation on Activation Energy

Deamidation of asparagine (Asn) residues is a nonenzymatic post-translational modification of proteins. Asn deamidation is associated with pathogenesis of age-related diseases and hypofunction of monoclonal antibodies. Deamidation rate is known to be affected by the residue following Asn on the carb...

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Detalles Bibliográficos
Autores principales: Kato, Koichi, Nakayoshi, Tomoki, Kurimoto, Eiji, Oda, Akifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582646/
https://www.ncbi.nlm.nih.gov/pubmed/32987875
http://dx.doi.org/10.3390/ijms21197035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582646/
https://www.ncbi.nlm.nih.gov/pubmed/32987875
http://dx.doi.org/10.3390/ijms21197035

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