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Mechanisms of Deamidation of Asparagine Residues and Effects of Main-Chain Conformation on Activation Energy

Deamidation of asparagine (Asn) residues is a nonenzymatic post-translational modification of proteins. Asn deamidation is associated with pathogenesis of age-related diseases and hypofunction of monoclonal antibodies. Deamidation rate is known to be affected by the residue following Asn on the carb...

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Detalles Bibliográficos
Autores principales:	Kato, Koichi, Nakayoshi, Tomoki, Kurimoto, Eiji, Oda, Akifumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582646/ https://www.ncbi.nlm.nih.gov/pubmed/32987875 http://dx.doi.org/10.3390/ijms21197035

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