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Saccharomyces Cerevisiae—An Interesting Producer of Bioactive Plant Polyphenolic Metabolites
Secondary phenolic metabolites are defined as valuable natural products synthesized by different organisms that are not essential for growth and development. These compounds play an essential role in plant defense mechanisms and an important role in the pharmaceutical, cosmetics, food, and agricultu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582661/ https://www.ncbi.nlm.nih.gov/pubmed/33027901 http://dx.doi.org/10.3390/ijms21197343 |
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author | Chrzanowski, Grzegorz |
author_facet | Chrzanowski, Grzegorz |
author_sort | Chrzanowski, Grzegorz |
collection | PubMed |
description | Secondary phenolic metabolites are defined as valuable natural products synthesized by different organisms that are not essential for growth and development. These compounds play an essential role in plant defense mechanisms and an important role in the pharmaceutical, cosmetics, food, and agricultural industries. Despite the vast chemical diversity of natural compounds, their content in plants is very low, and, as a consequence, this eliminates the possibility of the production of these interesting secondary metabolites from plants. Therefore, microorganisms are widely used as cell factories by industrial biotechnology, in the production of different non-native compounds. Among microorganisms commonly used in biotechnological applications, yeast are a prominent host for the diverse secondary metabolite biosynthetic pathways. Saccharomyces cerevisiae is often regarded as a better host organism for the heterologous production of phenolic compounds, particularly if the expression of different plant genes is necessary. |
format | Online Article Text |
id | pubmed-7582661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75826612020-10-28 Saccharomyces Cerevisiae—An Interesting Producer of Bioactive Plant Polyphenolic Metabolites Chrzanowski, Grzegorz Int J Mol Sci Review Secondary phenolic metabolites are defined as valuable natural products synthesized by different organisms that are not essential for growth and development. These compounds play an essential role in plant defense mechanisms and an important role in the pharmaceutical, cosmetics, food, and agricultural industries. Despite the vast chemical diversity of natural compounds, their content in plants is very low, and, as a consequence, this eliminates the possibility of the production of these interesting secondary metabolites from plants. Therefore, microorganisms are widely used as cell factories by industrial biotechnology, in the production of different non-native compounds. Among microorganisms commonly used in biotechnological applications, yeast are a prominent host for the diverse secondary metabolite biosynthetic pathways. Saccharomyces cerevisiae is often regarded as a better host organism for the heterologous production of phenolic compounds, particularly if the expression of different plant genes is necessary. MDPI 2020-10-05 /pmc/articles/PMC7582661/ /pubmed/33027901 http://dx.doi.org/10.3390/ijms21197343 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chrzanowski, Grzegorz Saccharomyces Cerevisiae—An Interesting Producer of Bioactive Plant Polyphenolic Metabolites |
title | Saccharomyces Cerevisiae—An Interesting Producer of Bioactive Plant Polyphenolic Metabolites |
title_full | Saccharomyces Cerevisiae—An Interesting Producer of Bioactive Plant Polyphenolic Metabolites |
title_fullStr | Saccharomyces Cerevisiae—An Interesting Producer of Bioactive Plant Polyphenolic Metabolites |
title_full_unstemmed | Saccharomyces Cerevisiae—An Interesting Producer of Bioactive Plant Polyphenolic Metabolites |
title_short | Saccharomyces Cerevisiae—An Interesting Producer of Bioactive Plant Polyphenolic Metabolites |
title_sort | saccharomyces cerevisiae—an interesting producer of bioactive plant polyphenolic metabolites |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582661/ https://www.ncbi.nlm.nih.gov/pubmed/33027901 http://dx.doi.org/10.3390/ijms21197343 |
work_keys_str_mv | AT chrzanowskigrzegorz saccharomycescerevisiaeaninterestingproducerofbioactiveplantpolyphenolicmetabolites |