A Series of Isatin-Hydrazones with Cytotoxic Activity and CDK2 Kinase Inhibitory Activity: A Potential Type II ATP Competitive Inhibitor

Isatin derivatives potentially act on various biological targets. In this article, a series of novel isatin-hydrazones were synthesized in excellent yields. Their cytotoxicity was tested against human breast adenocarcinoma (MCF7) and human ovary adenocarcinoma (A2780) cell lines using MTT assay. Com...

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Detalles Bibliográficos
Autores principales: Al-Salem, Huda S., Arifuzzaman, Md, Alkahtani, Hamad M., Abdalla, Ashraf N., Issa, Iman S., Alqathama, Aljawharah, Albalawi, Fatemah S., Rahman, A. F. M. Motiur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582667/
https://www.ncbi.nlm.nih.gov/pubmed/32992673
http://dx.doi.org/10.3390/molecules25194400

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