Cooperative Binding of the Cationic Porphyrin Tris-T4 Enhances Catalytic Activity of 20S Proteasome Unveiling a Complex Distribution of Functional States

The present study provides new evidence that cationic porphyrins may be considered as tunable platforms to interfere with the structural “key code” present on the 20S proteasome α-rings and, by consequence, with its catalytic activity. Here, we describe the functional and conformational effects on t...

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Detalles Bibliográficos
Autores principales: Santoro, Anna Maria, D’Urso, Alessandro, Cunsolo, Alessandra, Milardi, Danilo, Purrello, Roberto, Sbardella, Diego, Tundo, Grazia R., Diana, Donatella, Fattorusso, Roberto, Dato, Antonio Di, Paladino, Antonella, Persico, Marco, Coletta, Massimo, Fattorusso, Caterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582714/
https://www.ncbi.nlm.nih.gov/pubmed/33003385
http://dx.doi.org/10.3390/ijms21197190

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