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Chaperone Sigma1R and Antidepressant Effect

This review analyzes the current scientific literature on the role of the Sigma1R chaperone in the pathogenesis of depressive disorders and pharmacodynamics of antidepressants. As a result of ligand activation, Sigma1R is capable of intracellular translocation from the endoplasmic reticulum (ER) int...

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Detalles Bibliográficos
Autores principales: Voronin, Mikhail V., Vakhitova, Yulia V., Seredenin, Sergei B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582751/
https://www.ncbi.nlm.nih.gov/pubmed/32992988
http://dx.doi.org/10.3390/ijms21197088
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author Voronin, Mikhail V.
Vakhitova, Yulia V.
Seredenin, Sergei B.
author_facet Voronin, Mikhail V.
Vakhitova, Yulia V.
Seredenin, Sergei B.
author_sort Voronin, Mikhail V.
collection PubMed
description This review analyzes the current scientific literature on the role of the Sigma1R chaperone in the pathogenesis of depressive disorders and pharmacodynamics of antidepressants. As a result of ligand activation, Sigma1R is capable of intracellular translocation from the endoplasmic reticulum (ER) into the region of nuclear and cellular membranes, where it interacts with resident proteins. This unique property of Sigma1R provides regulation of various receptors, ion channels, enzymes, and transcriptional factors. The current review demonstrates the contribution of the Sigma1R chaperone to the regulation of molecular mechanisms involved in the antidepressant effect.
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spelling pubmed-75827512020-10-28 Chaperone Sigma1R and Antidepressant Effect Voronin, Mikhail V. Vakhitova, Yulia V. Seredenin, Sergei B. Int J Mol Sci Review This review analyzes the current scientific literature on the role of the Sigma1R chaperone in the pathogenesis of depressive disorders and pharmacodynamics of antidepressants. As a result of ligand activation, Sigma1R is capable of intracellular translocation from the endoplasmic reticulum (ER) into the region of nuclear and cellular membranes, where it interacts with resident proteins. This unique property of Sigma1R provides regulation of various receptors, ion channels, enzymes, and transcriptional factors. The current review demonstrates the contribution of the Sigma1R chaperone to the regulation of molecular mechanisms involved in the antidepressant effect. MDPI 2020-09-25 /pmc/articles/PMC7582751/ /pubmed/32992988 http://dx.doi.org/10.3390/ijms21197088 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Voronin, Mikhail V.
Vakhitova, Yulia V.
Seredenin, Sergei B.
Chaperone Sigma1R and Antidepressant Effect
title Chaperone Sigma1R and Antidepressant Effect
title_full Chaperone Sigma1R and Antidepressant Effect
title_fullStr Chaperone Sigma1R and Antidepressant Effect
title_full_unstemmed Chaperone Sigma1R and Antidepressant Effect
title_short Chaperone Sigma1R and Antidepressant Effect
title_sort chaperone sigma1r and antidepressant effect
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582751/
https://www.ncbi.nlm.nih.gov/pubmed/32992988
http://dx.doi.org/10.3390/ijms21197088
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