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Chaperone Sigma1R and Antidepressant Effect
This review analyzes the current scientific literature on the role of the Sigma1R chaperone in the pathogenesis of depressive disorders and pharmacodynamics of antidepressants. As a result of ligand activation, Sigma1R is capable of intracellular translocation from the endoplasmic reticulum (ER) int...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582751/ https://www.ncbi.nlm.nih.gov/pubmed/32992988 http://dx.doi.org/10.3390/ijms21197088 |
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author | Voronin, Mikhail V. Vakhitova, Yulia V. Seredenin, Sergei B. |
author_facet | Voronin, Mikhail V. Vakhitova, Yulia V. Seredenin, Sergei B. |
author_sort | Voronin, Mikhail V. |
collection | PubMed |
description | This review analyzes the current scientific literature on the role of the Sigma1R chaperone in the pathogenesis of depressive disorders and pharmacodynamics of antidepressants. As a result of ligand activation, Sigma1R is capable of intracellular translocation from the endoplasmic reticulum (ER) into the region of nuclear and cellular membranes, where it interacts with resident proteins. This unique property of Sigma1R provides regulation of various receptors, ion channels, enzymes, and transcriptional factors. The current review demonstrates the contribution of the Sigma1R chaperone to the regulation of molecular mechanisms involved in the antidepressant effect. |
format | Online Article Text |
id | pubmed-7582751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75827512020-10-28 Chaperone Sigma1R and Antidepressant Effect Voronin, Mikhail V. Vakhitova, Yulia V. Seredenin, Sergei B. Int J Mol Sci Review This review analyzes the current scientific literature on the role of the Sigma1R chaperone in the pathogenesis of depressive disorders and pharmacodynamics of antidepressants. As a result of ligand activation, Sigma1R is capable of intracellular translocation from the endoplasmic reticulum (ER) into the region of nuclear and cellular membranes, where it interacts with resident proteins. This unique property of Sigma1R provides regulation of various receptors, ion channels, enzymes, and transcriptional factors. The current review demonstrates the contribution of the Sigma1R chaperone to the regulation of molecular mechanisms involved in the antidepressant effect. MDPI 2020-09-25 /pmc/articles/PMC7582751/ /pubmed/32992988 http://dx.doi.org/10.3390/ijms21197088 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Voronin, Mikhail V. Vakhitova, Yulia V. Seredenin, Sergei B. Chaperone Sigma1R and Antidepressant Effect |
title | Chaperone Sigma1R and Antidepressant Effect |
title_full | Chaperone Sigma1R and Antidepressant Effect |
title_fullStr | Chaperone Sigma1R and Antidepressant Effect |
title_full_unstemmed | Chaperone Sigma1R and Antidepressant Effect |
title_short | Chaperone Sigma1R and Antidepressant Effect |
title_sort | chaperone sigma1r and antidepressant effect |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582751/ https://www.ncbi.nlm.nih.gov/pubmed/32992988 http://dx.doi.org/10.3390/ijms21197088 |
work_keys_str_mv | AT voroninmikhailv chaperonesigma1randantidepressanteffect AT vakhitovayuliav chaperonesigma1randantidepressanteffect AT seredeninsergeib chaperonesigma1randantidepressanteffect |