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Drug Delivery Systems of Natural Products in Oncology

In recent decades, increasing interest in the use of natural products in anticancer therapy field has been observed, mainly due to unsolved drug-resistance problems. The antitumoral effect of natural compounds involving different signaling pathways and cellular mechanisms has been largely demonstrat...

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Detalles Bibliográficos
Autores principales: Colone, Marisa, Calcabrini, Annarica, Stringaro, Annarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582809/
https://www.ncbi.nlm.nih.gov/pubmed/33036240
http://dx.doi.org/10.3390/molecules25194560
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author Colone, Marisa
Calcabrini, Annarica
Stringaro, Annarita
author_facet Colone, Marisa
Calcabrini, Annarica
Stringaro, Annarita
author_sort Colone, Marisa
collection PubMed
description In recent decades, increasing interest in the use of natural products in anticancer therapy field has been observed, mainly due to unsolved drug-resistance problems. The antitumoral effect of natural compounds involving different signaling pathways and cellular mechanisms has been largely demonstrated in in vitro and in vivo studies. The encapsulation of natural products into different delivery systems may lead to a significant enhancement of their anticancer efficacy by increasing in vivo stability and bioavailability, reducing side adverse effects and improving target-specific activity. This review will focus on research studies related to nanostructured systems containing natural compounds for new drug delivery tools in anticancer therapies.
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spelling pubmed-75828092020-10-28 Drug Delivery Systems of Natural Products in Oncology Colone, Marisa Calcabrini, Annarica Stringaro, Annarita Molecules Review In recent decades, increasing interest in the use of natural products in anticancer therapy field has been observed, mainly due to unsolved drug-resistance problems. The antitumoral effect of natural compounds involving different signaling pathways and cellular mechanisms has been largely demonstrated in in vitro and in vivo studies. The encapsulation of natural products into different delivery systems may lead to a significant enhancement of their anticancer efficacy by increasing in vivo stability and bioavailability, reducing side adverse effects and improving target-specific activity. This review will focus on research studies related to nanostructured systems containing natural compounds for new drug delivery tools in anticancer therapies. MDPI 2020-10-06 /pmc/articles/PMC7582809/ /pubmed/33036240 http://dx.doi.org/10.3390/molecules25194560 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Colone, Marisa
Calcabrini, Annarica
Stringaro, Annarita
Drug Delivery Systems of Natural Products in Oncology
title Drug Delivery Systems of Natural Products in Oncology
title_full Drug Delivery Systems of Natural Products in Oncology
title_fullStr Drug Delivery Systems of Natural Products in Oncology
title_full_unstemmed Drug Delivery Systems of Natural Products in Oncology
title_short Drug Delivery Systems of Natural Products in Oncology
title_sort drug delivery systems of natural products in oncology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582809/
https://www.ncbi.nlm.nih.gov/pubmed/33036240
http://dx.doi.org/10.3390/molecules25194560
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