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Total Synthesis of Novel Skeleton Flavan-Alkaloids
The first total synthesis of novel skeleton natural compounds kinkeloids A and B, a group of newly discovered flavan alkaloids isolated from the African plant Combretum micranthum, are described in this study. The key and final step are achieved by Mannich reaction, through which the piperidine moie...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582810/ https://www.ncbi.nlm.nih.gov/pubmed/33007965 http://dx.doi.org/10.3390/molecules25194491 |
| _version_ | 1783599276166742016 |
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| author | Zhen, Jing Simon, James E. Wu, Qingli |
| author_facet | Zhen, Jing Simon, James E. Wu, Qingli |
| author_sort | Zhen, Jing |
| collection | PubMed |
| description | The first total synthesis of novel skeleton natural compounds kinkeloids A and B, a group of newly discovered flavan alkaloids isolated from the African plant Combretum micranthum, are described in this study. The key and final step are achieved by Mannich reaction, through which the piperidine moiety couples to the flavan moiety. The identities of synthesized kinkeloids were further confirmed through a comparison with the ones in the plant leaves extract using LC/MS. |
| format | Online Article Text |
| id | pubmed-7582810 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-75828102020-10-28 Total Synthesis of Novel Skeleton Flavan-Alkaloids Zhen, Jing Simon, James E. Wu, Qingli Molecules Article The first total synthesis of novel skeleton natural compounds kinkeloids A and B, a group of newly discovered flavan alkaloids isolated from the African plant Combretum micranthum, are described in this study. The key and final step are achieved by Mannich reaction, through which the piperidine moiety couples to the flavan moiety. The identities of synthesized kinkeloids were further confirmed through a comparison with the ones in the plant leaves extract using LC/MS. MDPI 2020-09-30 /pmc/articles/PMC7582810/ /pubmed/33007965 http://dx.doi.org/10.3390/molecules25194491 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Zhen, Jing Simon, James E. Wu, Qingli Total Synthesis of Novel Skeleton Flavan-Alkaloids |
| title | Total Synthesis of Novel Skeleton Flavan-Alkaloids |
| title_full | Total Synthesis of Novel Skeleton Flavan-Alkaloids |
| title_fullStr | Total Synthesis of Novel Skeleton Flavan-Alkaloids |
| title_full_unstemmed | Total Synthesis of Novel Skeleton Flavan-Alkaloids |
| title_short | Total Synthesis of Novel Skeleton Flavan-Alkaloids |
| title_sort | total synthesis of novel skeleton flavan-alkaloids |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582810/ https://www.ncbi.nlm.nih.gov/pubmed/33007965 http://dx.doi.org/10.3390/molecules25194491 |
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