Cargando…
Using advanced oxidation protein products and ischaemia-modified albumin to monitor oxidative stress levels in patients with drug-induced liver injury
Increased oxidative stress levels play a key role in idiosyncratic drug-induced liver injury (DILI) pathogenesis. To investigated whether advanced oxidation protein products (AOPPs) and ischaemia-modified albumin (IMA) can be used to monitor oxidative stress in DILI patients and to assess disease se...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582878/ https://www.ncbi.nlm.nih.gov/pubmed/33093629 http://dx.doi.org/10.1038/s41598-020-75141-2 |
_version_ | 1783599292187934720 |
---|---|
author | Xiao, Lan-Lan Zhang, Fen Zhao, Ya-Lei Zhang, Ling-Jian Xie, Zhong-Yang Huang, Kai-Zhou Ouyang, Xiao-Xi Wu, Xiao-Xin Xu, Xiao-Wei Li, Lan-Juan |
author_facet | Xiao, Lan-Lan Zhang, Fen Zhao, Ya-Lei Zhang, Ling-Jian Xie, Zhong-Yang Huang, Kai-Zhou Ouyang, Xiao-Xi Wu, Xiao-Xin Xu, Xiao-Wei Li, Lan-Juan |
author_sort | Xiao, Lan-Lan |
collection | PubMed |
description | Increased oxidative stress levels play a key role in idiosyncratic drug-induced liver injury (DILI) pathogenesis. To investigated whether advanced oxidation protein products (AOPPs) and ischaemia-modified albumin (IMA) can be used to monitor oxidative stress in DILI patients and to assess disease severity. We performed spectrophotometric assays to assess AOPPs and IMA in 68 DILI patients with severity grade 0–2 (non-severe group), 60 with severity grade 3–5 (severe group), and 38 healthy controls. The results showed that baseline AOPPs and IMA serum levels and AOPPs/albumin and IMA/albumin ratios were significantly higher in DILI patients than in healthy controls. Besides, in comparison to the non-severe group, the severe group showed higher baseline AOPPs and IMA serum levels and AOPPs/albumin and IMA/albumin ratios. AOPPs and IMA serum levels and AOPPs/albumin and IMA/albumin ratios decreased after treatment in both patient groups. Combining the correlation analysis and areas under the receiver operating curve (AUROCs) analysis results, that IMA outperformed to be one is the most reliable marker to assess disease severity of DILI. Our findings indicated that AOPPs and IMA can serve as key biomarkers for monitoring oxidative stress levels in DILI patients and can indicate disease severity. The IMA outperformed to be one of the most reliable oxidative stress biomarkers to assess disease severity of DILI. |
format | Online Article Text |
id | pubmed-7582878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-75828782020-10-23 Using advanced oxidation protein products and ischaemia-modified albumin to monitor oxidative stress levels in patients with drug-induced liver injury Xiao, Lan-Lan Zhang, Fen Zhao, Ya-Lei Zhang, Ling-Jian Xie, Zhong-Yang Huang, Kai-Zhou Ouyang, Xiao-Xi Wu, Xiao-Xin Xu, Xiao-Wei Li, Lan-Juan Sci Rep Article Increased oxidative stress levels play a key role in idiosyncratic drug-induced liver injury (DILI) pathogenesis. To investigated whether advanced oxidation protein products (AOPPs) and ischaemia-modified albumin (IMA) can be used to monitor oxidative stress in DILI patients and to assess disease severity. We performed spectrophotometric assays to assess AOPPs and IMA in 68 DILI patients with severity grade 0–2 (non-severe group), 60 with severity grade 3–5 (severe group), and 38 healthy controls. The results showed that baseline AOPPs and IMA serum levels and AOPPs/albumin and IMA/albumin ratios were significantly higher in DILI patients than in healthy controls. Besides, in comparison to the non-severe group, the severe group showed higher baseline AOPPs and IMA serum levels and AOPPs/albumin and IMA/albumin ratios. AOPPs and IMA serum levels and AOPPs/albumin and IMA/albumin ratios decreased after treatment in both patient groups. Combining the correlation analysis and areas under the receiver operating curve (AUROCs) analysis results, that IMA outperformed to be one is the most reliable marker to assess disease severity of DILI. Our findings indicated that AOPPs and IMA can serve as key biomarkers for monitoring oxidative stress levels in DILI patients and can indicate disease severity. The IMA outperformed to be one of the most reliable oxidative stress biomarkers to assess disease severity of DILI. Nature Publishing Group UK 2020-10-22 /pmc/articles/PMC7582878/ /pubmed/33093629 http://dx.doi.org/10.1038/s41598-020-75141-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Xiao, Lan-Lan Zhang, Fen Zhao, Ya-Lei Zhang, Ling-Jian Xie, Zhong-Yang Huang, Kai-Zhou Ouyang, Xiao-Xi Wu, Xiao-Xin Xu, Xiao-Wei Li, Lan-Juan Using advanced oxidation protein products and ischaemia-modified albumin to monitor oxidative stress levels in patients with drug-induced liver injury |
title | Using advanced oxidation protein products and ischaemia-modified albumin to monitor oxidative stress levels in patients with drug-induced liver injury |
title_full | Using advanced oxidation protein products and ischaemia-modified albumin to monitor oxidative stress levels in patients with drug-induced liver injury |
title_fullStr | Using advanced oxidation protein products and ischaemia-modified albumin to monitor oxidative stress levels in patients with drug-induced liver injury |
title_full_unstemmed | Using advanced oxidation protein products and ischaemia-modified albumin to monitor oxidative stress levels in patients with drug-induced liver injury |
title_short | Using advanced oxidation protein products and ischaemia-modified albumin to monitor oxidative stress levels in patients with drug-induced liver injury |
title_sort | using advanced oxidation protein products and ischaemia-modified albumin to monitor oxidative stress levels in patients with drug-induced liver injury |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582878/ https://www.ncbi.nlm.nih.gov/pubmed/33093629 http://dx.doi.org/10.1038/s41598-020-75141-2 |
work_keys_str_mv | AT xiaolanlan usingadvancedoxidationproteinproductsandischaemiamodifiedalbumintomonitoroxidativestresslevelsinpatientswithdruginducedliverinjury AT zhangfen usingadvancedoxidationproteinproductsandischaemiamodifiedalbumintomonitoroxidativestresslevelsinpatientswithdruginducedliverinjury AT zhaoyalei usingadvancedoxidationproteinproductsandischaemiamodifiedalbumintomonitoroxidativestresslevelsinpatientswithdruginducedliverinjury AT zhanglingjian usingadvancedoxidationproteinproductsandischaemiamodifiedalbumintomonitoroxidativestresslevelsinpatientswithdruginducedliverinjury AT xiezhongyang usingadvancedoxidationproteinproductsandischaemiamodifiedalbumintomonitoroxidativestresslevelsinpatientswithdruginducedliverinjury AT huangkaizhou usingadvancedoxidationproteinproductsandischaemiamodifiedalbumintomonitoroxidativestresslevelsinpatientswithdruginducedliverinjury AT ouyangxiaoxi usingadvancedoxidationproteinproductsandischaemiamodifiedalbumintomonitoroxidativestresslevelsinpatientswithdruginducedliverinjury AT wuxiaoxin usingadvancedoxidationproteinproductsandischaemiamodifiedalbumintomonitoroxidativestresslevelsinpatientswithdruginducedliverinjury AT xuxiaowei usingadvancedoxidationproteinproductsandischaemiamodifiedalbumintomonitoroxidativestresslevelsinpatientswithdruginducedliverinjury AT lilanjuan usingadvancedoxidationproteinproductsandischaemiamodifiedalbumintomonitoroxidativestresslevelsinpatientswithdruginducedliverinjury |