The ALS-Related σ1R E102Q Mutant Eludes Ligand Control and Exhibits Anomalous Response to Calcium

Sigma receptor type 1 (σ1R) is a transmembrane protein expressed throughout the central nervous system and in certain peripheral tissues. The human σ1R E102Q mutation causes juvenile amyotrophic lateral sclerosis (ALS), likely by inducing a series of alterations in calcium efflux from the endoplasmi...

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Detalles Bibliográficos
Autores principales: Rodríguez-Muñoz, María, Cortés-Montero, Elsa, Garzón-Niño, Javier, Sánchez-Blázquez, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582951/
https://www.ncbi.nlm.nih.gov/pubmed/33020464
http://dx.doi.org/10.3390/ijms21197339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582951/
https://www.ncbi.nlm.nih.gov/pubmed/33020464
http://dx.doi.org/10.3390/ijms21197339

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