A Fluorescence Polarization-Based High-Throughput Screen to Identify the First Small-Molecule Modulators of the Human Adenylyltransferase HYPE/FICD

The covalent transfer of the AMP portion of ATP onto a target protein—termed adenylylation or AMPylation—by the human Fic protein HYPE/FICD has recently garnered attention as a key regulatory mechanism in endoplasmic reticulum homeostasis, neurodegeneration, and neurogenesis. As a central player in...

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Detalles Bibliográficos
Autores principales: Camara, Ali, George, Alyssa, Hebner, Evan, Mahmood, Anika, Paluru, Jashun, Mattoo, Seema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582957/
https://www.ncbi.nlm.nih.gov/pubmed/32992526
http://dx.doi.org/10.3390/ijms21197128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582957/
https://www.ncbi.nlm.nih.gov/pubmed/32992526
http://dx.doi.org/10.3390/ijms21197128

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