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The Brain–Gut–Microbiome Axis in Psychiatry
Beginning with the concept of the brain–gut axis, the importance of the interaction between the brain and the gastrointestinal tract has been extended to the microbiome with increasing clinical applications. With the recent development of various techniques for microbiome analysis, the number of rel...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583027/ https://www.ncbi.nlm.nih.gov/pubmed/32992484 http://dx.doi.org/10.3390/ijms21197122 |
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author | Jang, Seung-Ho Woo, Young Sup Lee, Sang-Yeol Bahk, Won-Myong |
author_facet | Jang, Seung-Ho Woo, Young Sup Lee, Sang-Yeol Bahk, Won-Myong |
author_sort | Jang, Seung-Ho |
collection | PubMed |
description | Beginning with the concept of the brain–gut axis, the importance of the interaction between the brain and the gastrointestinal tract has been extended to the microbiome with increasing clinical applications. With the recent development of various techniques for microbiome analysis, the number of relevant preclinical and clinical studies on animals and human subjects has rapidly increased. Various psychotic symptoms affect the intestinal microbiome through the hypothalamus–pituitary–adrenal gland axis. Conversely, the intestinal microbiome regulates the gastrointestinal tract environment and affects psychological factors by means of the microorganisms or their metabolites, either acting directly on the brain or through the synthesis of various neurotransmitters. This review discusses the clinical applicability of the brain–gut–microbiome axis and directions for improving psychological symptoms based on the studies published to date. |
format | Online Article Text |
id | pubmed-7583027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75830272020-10-28 The Brain–Gut–Microbiome Axis in Psychiatry Jang, Seung-Ho Woo, Young Sup Lee, Sang-Yeol Bahk, Won-Myong Int J Mol Sci Review Beginning with the concept of the brain–gut axis, the importance of the interaction between the brain and the gastrointestinal tract has been extended to the microbiome with increasing clinical applications. With the recent development of various techniques for microbiome analysis, the number of relevant preclinical and clinical studies on animals and human subjects has rapidly increased. Various psychotic symptoms affect the intestinal microbiome through the hypothalamus–pituitary–adrenal gland axis. Conversely, the intestinal microbiome regulates the gastrointestinal tract environment and affects psychological factors by means of the microorganisms or their metabolites, either acting directly on the brain or through the synthesis of various neurotransmitters. This review discusses the clinical applicability of the brain–gut–microbiome axis and directions for improving psychological symptoms based on the studies published to date. MDPI 2020-09-27 /pmc/articles/PMC7583027/ /pubmed/32992484 http://dx.doi.org/10.3390/ijms21197122 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jang, Seung-Ho Woo, Young Sup Lee, Sang-Yeol Bahk, Won-Myong The Brain–Gut–Microbiome Axis in Psychiatry |
title | The Brain–Gut–Microbiome Axis in Psychiatry |
title_full | The Brain–Gut–Microbiome Axis in Psychiatry |
title_fullStr | The Brain–Gut–Microbiome Axis in Psychiatry |
title_full_unstemmed | The Brain–Gut–Microbiome Axis in Psychiatry |
title_short | The Brain–Gut–Microbiome Axis in Psychiatry |
title_sort | brain–gut–microbiome axis in psychiatry |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583027/ https://www.ncbi.nlm.nih.gov/pubmed/32992484 http://dx.doi.org/10.3390/ijms21197122 |
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