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Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells

BACKGROUND: Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance. The chemotherapeutic agent etoposide (VP-16) has been used clinically in the treatment of lung cancer but possess different sensitivity and efficacy towards SCLC and NSCLC. He...

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Detalles Bibliográficos
Autores principales:	Dong, Qi, Zhou, Chenkang, Ren, Haodong, Zhang, Zhijian, Cheng, Feng, Xiong, Zhenkai, Chen, Chuantao, Yang, Jianke, Gao, Jiguang, Zhang, Yao, Xu, Lei, Fang, Jian, Cao, Yuxiang, Wei, Huijun, Wu, Zhihao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583203/ https://www.ncbi.nlm.nih.gov/pubmed/33097055 http://dx.doi.org/10.1186/s12964-020-00653-3

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