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Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites
OBJECTIVE: To identify factors associated with outcome of septic shock patients receiving high dose noradrenaline according to three primary infection sites. METHODS: This retrospective study was based on data from a publicly available ICU database (Medical Information Mart for Intensive Care [MIMIC...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583396/ https://www.ncbi.nlm.nih.gov/pubmed/31530058 http://dx.doi.org/10.1177/0300060519874545 |
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author | Wu, Kang-song Gu, Dan-yan Wang, Ting-ting Yu, Bu-wen Pan, Kong-han Zhou, Jian-cang |
author_facet | Wu, Kang-song Gu, Dan-yan Wang, Ting-ting Yu, Bu-wen Pan, Kong-han Zhou, Jian-cang |
author_sort | Wu, Kang-song |
collection | PubMed |
description | OBJECTIVE: To identify factors associated with outcome of septic shock patients receiving high dose noradrenaline according to three primary infection sites. METHODS: This retrospective study was based on data from a publicly available ICU database (Medical Information Mart for Intensive Care [MIMIC] III. Septic shock patients receiving high dose (≥1 μg/kg per min) noradrenaline and ≥18 years were identified and their characteristics and outcomes were compared according to three primary infection sites (abdominal, respiratory and urinary tract). RESULTS: 154 septic shock patients who received high doses of noradrenaline were identified; (89 [58%] had a respiratory infection, 41 [27%] an abdominal infection and 24 [16%] a urinary infection). There were no differences among the three infection groups in duration/maximum dosage of noradrenaline, length of stay in the ICU/hospital, do not resuscitate (DNR) rates, hypertension and adequate antimicrobial therapy. Patients with urinary infections had a lower risk of death at 28-days compared with those with abdominal or respiratory infections. CONCLUSIONS: The prognosis for septic shock patients receiving high dose noradrenaline is poor. Patients with abdominal or respiratory infections are at higher risk of death compared with those with urinary infections. |
format | Online Article Text |
id | pubmed-7583396 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-75833962020-11-03 Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites Wu, Kang-song Gu, Dan-yan Wang, Ting-ting Yu, Bu-wen Pan, Kong-han Zhou, Jian-cang J Int Med Res Special Issue: Infection and Bacterial Resistance OBJECTIVE: To identify factors associated with outcome of septic shock patients receiving high dose noradrenaline according to three primary infection sites. METHODS: This retrospective study was based on data from a publicly available ICU database (Medical Information Mart for Intensive Care [MIMIC] III. Septic shock patients receiving high dose (≥1 μg/kg per min) noradrenaline and ≥18 years were identified and their characteristics and outcomes were compared according to three primary infection sites (abdominal, respiratory and urinary tract). RESULTS: 154 septic shock patients who received high doses of noradrenaline were identified; (89 [58%] had a respiratory infection, 41 [27%] an abdominal infection and 24 [16%] a urinary infection). There were no differences among the three infection groups in duration/maximum dosage of noradrenaline, length of stay in the ICU/hospital, do not resuscitate (DNR) rates, hypertension and adequate antimicrobial therapy. Patients with urinary infections had a lower risk of death at 28-days compared with those with abdominal or respiratory infections. CONCLUSIONS: The prognosis for septic shock patients receiving high dose noradrenaline is poor. Patients with abdominal or respiratory infections are at higher risk of death compared with those with urinary infections. SAGE Publications 2019-09-17 /pmc/articles/PMC7583396/ /pubmed/31530058 http://dx.doi.org/10.1177/0300060519874545 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Special Issue: Infection and Bacterial Resistance Wu, Kang-song Gu, Dan-yan Wang, Ting-ting Yu, Bu-wen Pan, Kong-han Zhou, Jian-cang Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites |
title | Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites |
title_full | Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites |
title_fullStr | Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites |
title_full_unstemmed | Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites |
title_short | Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites |
title_sort | factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites |
topic | Special Issue: Infection and Bacterial Resistance |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583396/ https://www.ncbi.nlm.nih.gov/pubmed/31530058 http://dx.doi.org/10.1177/0300060519874545 |
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