Cargando…

Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites

OBJECTIVE: To identify factors associated with outcome of septic shock patients receiving high dose noradrenaline according to three primary infection sites. METHODS: This retrospective study was based on data from a publicly available ICU database (Medical Information Mart for Intensive Care [MIMIC...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Kang-song, Gu, Dan-yan, Wang, Ting-ting, Yu, Bu-wen, Pan, Kong-han, Zhou, Jian-cang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583396/
https://www.ncbi.nlm.nih.gov/pubmed/31530058
http://dx.doi.org/10.1177/0300060519874545
_version_ 1783599387743617024
author Wu, Kang-song
Gu, Dan-yan
Wang, Ting-ting
Yu, Bu-wen
Pan, Kong-han
Zhou, Jian-cang
author_facet Wu, Kang-song
Gu, Dan-yan
Wang, Ting-ting
Yu, Bu-wen
Pan, Kong-han
Zhou, Jian-cang
author_sort Wu, Kang-song
collection PubMed
description OBJECTIVE: To identify factors associated with outcome of septic shock patients receiving high dose noradrenaline according to three primary infection sites. METHODS: This retrospective study was based on data from a publicly available ICU database (Medical Information Mart for Intensive Care [MIMIC] III. Septic shock patients receiving high dose (≥1 μg/kg per min) noradrenaline and ≥18 years were identified and their characteristics and outcomes were compared according to three primary infection sites (abdominal, respiratory and urinary tract). RESULTS: 154 septic shock patients who received high doses of noradrenaline were identified; (89 [58%] had a respiratory infection, 41 [27%] an abdominal infection and 24 [16%] a urinary infection). There were no differences among the three infection groups in duration/maximum dosage of noradrenaline, length of stay in the ICU/hospital, do not resuscitate (DNR) rates, hypertension and adequate antimicrobial therapy. Patients with urinary infections had a lower risk of death at 28-days compared with those with abdominal or respiratory infections. CONCLUSIONS: The prognosis for septic shock patients receiving high dose noradrenaline is poor. Patients with abdominal or respiratory infections are at higher risk of death compared with those with urinary infections.
format Online
Article
Text
id pubmed-7583396
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-75833962020-11-03 Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites Wu, Kang-song Gu, Dan-yan Wang, Ting-ting Yu, Bu-wen Pan, Kong-han Zhou, Jian-cang J Int Med Res Special Issue: Infection and Bacterial Resistance OBJECTIVE: To identify factors associated with outcome of septic shock patients receiving high dose noradrenaline according to three primary infection sites. METHODS: This retrospective study was based on data from a publicly available ICU database (Medical Information Mart for Intensive Care [MIMIC] III. Septic shock patients receiving high dose (≥1 μg/kg per min) noradrenaline and ≥18 years were identified and their characteristics and outcomes were compared according to three primary infection sites (abdominal, respiratory and urinary tract). RESULTS: 154 septic shock patients who received high doses of noradrenaline were identified; (89 [58%] had a respiratory infection, 41 [27%] an abdominal infection and 24 [16%] a urinary infection). There were no differences among the three infection groups in duration/maximum dosage of noradrenaline, length of stay in the ICU/hospital, do not resuscitate (DNR) rates, hypertension and adequate antimicrobial therapy. Patients with urinary infections had a lower risk of death at 28-days compared with those with abdominal or respiratory infections. CONCLUSIONS: The prognosis for septic shock patients receiving high dose noradrenaline is poor. Patients with abdominal or respiratory infections are at higher risk of death compared with those with urinary infections. SAGE Publications 2019-09-17 /pmc/articles/PMC7583396/ /pubmed/31530058 http://dx.doi.org/10.1177/0300060519874545 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Special Issue: Infection and Bacterial Resistance
Wu, Kang-song
Gu, Dan-yan
Wang, Ting-ting
Yu, Bu-wen
Pan, Kong-han
Zhou, Jian-cang
Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites
title Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites
title_full Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites
title_fullStr Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites
title_full_unstemmed Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites
title_short Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites
title_sort factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites
topic Special Issue: Infection and Bacterial Resistance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583396/
https://www.ncbi.nlm.nih.gov/pubmed/31530058
http://dx.doi.org/10.1177/0300060519874545
work_keys_str_mv AT wukangsong factorsassociatedwithoutcomesofsepticshockpatientsreceivinghighdosenoradrenalineaccordingtothreeprimaryinfectionsites
AT gudanyan factorsassociatedwithoutcomesofsepticshockpatientsreceivinghighdosenoradrenalineaccordingtothreeprimaryinfectionsites
AT wangtingting factorsassociatedwithoutcomesofsepticshockpatientsreceivinghighdosenoradrenalineaccordingtothreeprimaryinfectionsites
AT yubuwen factorsassociatedwithoutcomesofsepticshockpatientsreceivinghighdosenoradrenalineaccordingtothreeprimaryinfectionsites
AT pankonghan factorsassociatedwithoutcomesofsepticshockpatientsreceivinghighdosenoradrenalineaccordingtothreeprimaryinfectionsites
AT zhoujiancang factorsassociatedwithoutcomesofsepticshockpatientsreceivinghighdosenoradrenalineaccordingtothreeprimaryinfectionsites