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A clinical trial of IL-15 and IL-21 combination therapy for COVID-19 is warranted

Previous studies of SARS-CoV-2 viral infection suggest that both the humoral and cytotoxic arms of the immune system are weak in patients with severe COVID-19 disease when compared to mild disease. A cytokine storm is also induced in severe disease. IL-15 has been shown to support the cytotoxic arm...

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Autor principal: Wilz, Stephen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author. Published by Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583616/
https://www.ncbi.nlm.nih.gov/pubmed/33199178
http://dx.doi.org/10.1016/j.cytogfr.2020.10.005
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author Wilz, Stephen W.
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description Previous studies of SARS-CoV-2 viral infection suggest that both the humoral and cytotoxic arms of the immune system are weak in patients with severe COVID-19 disease when compared to mild disease. A cytokine storm is also induced in severe disease. IL-15 has been shown to support the cytotoxic arm of the immune response. IL-21 has been shown to support both the cytotoxic and humoral arms of the immune response. In addition, in some settings, Il-21 has been shown to actually decrease IL-6 and TNF-alpha production, reducing the inflammatory proteins involved in the cytokine storm. Furthermore, in other settings, the combination of IL-15 and IL-21 has been shown to be more effective than either interleukin alone in promoting an effective immune response. Therefore, a clinical trial that examines the use of the combination of IL-15 and IL-21 for COVID-19 patients is warranted.
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spelling pubmed-75836162020-10-26 A clinical trial of IL-15 and IL-21 combination therapy for COVID-19 is warranted Wilz, Stephen W. Cytokine Growth Factor Rev Article Previous studies of SARS-CoV-2 viral infection suggest that both the humoral and cytotoxic arms of the immune system are weak in patients with severe COVID-19 disease when compared to mild disease. A cytokine storm is also induced in severe disease. IL-15 has been shown to support the cytotoxic arm of the immune response. IL-21 has been shown to support both the cytotoxic and humoral arms of the immune response. In addition, in some settings, Il-21 has been shown to actually decrease IL-6 and TNF-alpha production, reducing the inflammatory proteins involved in the cytokine storm. Furthermore, in other settings, the combination of IL-15 and IL-21 has been shown to be more effective than either interleukin alone in promoting an effective immune response. Therefore, a clinical trial that examines the use of the combination of IL-15 and IL-21 for COVID-19 patients is warranted. The Author. Published by Elsevier Ltd. 2021-04 2020-10-23 /pmc/articles/PMC7583616/ /pubmed/33199178 http://dx.doi.org/10.1016/j.cytogfr.2020.10.005 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Wilz, Stephen W.
A clinical trial of IL-15 and IL-21 combination therapy for COVID-19 is warranted
title A clinical trial of IL-15 and IL-21 combination therapy for COVID-19 is warranted
title_full A clinical trial of IL-15 and IL-21 combination therapy for COVID-19 is warranted
title_fullStr A clinical trial of IL-15 and IL-21 combination therapy for COVID-19 is warranted
title_full_unstemmed A clinical trial of IL-15 and IL-21 combination therapy for COVID-19 is warranted
title_short A clinical trial of IL-15 and IL-21 combination therapy for COVID-19 is warranted
title_sort clinical trial of il-15 and il-21 combination therapy for covid-19 is warranted
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583616/
https://www.ncbi.nlm.nih.gov/pubmed/33199178
http://dx.doi.org/10.1016/j.cytogfr.2020.10.005
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