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Age and Sex Differences in Heart Rate Variability and Vagal Specific Patterns – Baependi Heart Study

BACKGROUND: Heart rate variability (HRV) is a noninvasive method for assessing autonomic function. Age, sex, and chronic conditions influence HRV. OBJECTIVES: Our aim was to evaluate HRV measures exploring differences by age, sex, and race in a sample from a rural area. METHODS: Analytical sample (n...

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Autores principales: Geovanini, Glaucylara Reis, Vasques, Enio Rodrigues, de Oliveira Alvim, Rafael, Mill, José Geraldo, Andreão, Rodrigo Varejão, Vasques, Bruna Kim, Pereira, Alexandre Costa, Krieger, Jose Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ubiquity Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583712/
https://www.ncbi.nlm.nih.gov/pubmed/33150136
http://dx.doi.org/10.5334/gh.873
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author Geovanini, Glaucylara Reis
Vasques, Enio Rodrigues
de Oliveira Alvim, Rafael
Mill, José Geraldo
Andreão, Rodrigo Varejão
Vasques, Bruna Kim
Pereira, Alexandre Costa
Krieger, Jose Eduardo
author_facet Geovanini, Glaucylara Reis
Vasques, Enio Rodrigues
de Oliveira Alvim, Rafael
Mill, José Geraldo
Andreão, Rodrigo Varejão
Vasques, Bruna Kim
Pereira, Alexandre Costa
Krieger, Jose Eduardo
author_sort Geovanini, Glaucylara Reis
collection PubMed
description BACKGROUND: Heart rate variability (HRV) is a noninvasive method for assessing autonomic function. Age, sex, and chronic conditions influence HRV. OBJECTIVES: Our aim was to evaluate HRV measures exploring differences by age, sex, and race in a sample from a rural area. METHODS: Analytical sample (n = 1,287) included participants from the 2010 to 2016 evaluation period of the Baependi Heart Study, a family-based cohort in Brazil. Participants underwent 24-hour Holter-ECG (Holter) monitoring. To derive population reference values, we restricted our analysis to a ‘healthy’ subset (i.e. absence of medical comorbidities). A confirmatory analysis was conducted with a subgroup sample that also had HRV derived from a resting ECG 10’-protocol obtained during the same time period. RESULTS: The ‘healthy’ subset included 543 participants. Mean age was 40 ± 14y, 41% were male, 74% self-referred as white and mean body-mass-index was 24 ± 3kg/m(2). Time domain HRV measures showed significant differences by age-decade and by sex. Higher values were observed for males across almost all age-groups. Parasympathetic associated variables (rMSSD and pNN50) showed a U-shaped distribution and reversal increase above 60y. Sympathetic-parasympathetic balance variables (SDNN, SDANN) decreased linearly by age. Race differences were no significant. We compared time domain variables with complete data (Holter and resting ECG) between ‘healthy’ versus ‘unhealthy’ groups. Higher HRV values were shown for the ‘healthy’ subset compared with the ‘unhealthy’ group. CONCLUSION: HRV measures vary across age and sex. A U-shaped pattern and a reversal increase in parasympathetic variables may reflect an age-related autonomic dysfunction even in healthy individuals that could be used as a predictor of disease development.
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spelling pubmed-75837122020-11-03 Age and Sex Differences in Heart Rate Variability and Vagal Specific Patterns – Baependi Heart Study Geovanini, Glaucylara Reis Vasques, Enio Rodrigues de Oliveira Alvim, Rafael Mill, José Geraldo Andreão, Rodrigo Varejão Vasques, Bruna Kim Pereira, Alexandre Costa Krieger, Jose Eduardo Glob Heart Original Research BACKGROUND: Heart rate variability (HRV) is a noninvasive method for assessing autonomic function. Age, sex, and chronic conditions influence HRV. OBJECTIVES: Our aim was to evaluate HRV measures exploring differences by age, sex, and race in a sample from a rural area. METHODS: Analytical sample (n = 1,287) included participants from the 2010 to 2016 evaluation period of the Baependi Heart Study, a family-based cohort in Brazil. Participants underwent 24-hour Holter-ECG (Holter) monitoring. To derive population reference values, we restricted our analysis to a ‘healthy’ subset (i.e. absence of medical comorbidities). A confirmatory analysis was conducted with a subgroup sample that also had HRV derived from a resting ECG 10’-protocol obtained during the same time period. RESULTS: The ‘healthy’ subset included 543 participants. Mean age was 40 ± 14y, 41% were male, 74% self-referred as white and mean body-mass-index was 24 ± 3kg/m(2). Time domain HRV measures showed significant differences by age-decade and by sex. Higher values were observed for males across almost all age-groups. Parasympathetic associated variables (rMSSD and pNN50) showed a U-shaped distribution and reversal increase above 60y. Sympathetic-parasympathetic balance variables (SDNN, SDANN) decreased linearly by age. Race differences were no significant. We compared time domain variables with complete data (Holter and resting ECG) between ‘healthy’ versus ‘unhealthy’ groups. Higher HRV values were shown for the ‘healthy’ subset compared with the ‘unhealthy’ group. CONCLUSION: HRV measures vary across age and sex. A U-shaped pattern and a reversal increase in parasympathetic variables may reflect an age-related autonomic dysfunction even in healthy individuals that could be used as a predictor of disease development. Ubiquity Press 2020-10-21 /pmc/articles/PMC7583712/ /pubmed/33150136 http://dx.doi.org/10.5334/gh.873 Text en Copyright: © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Research
Geovanini, Glaucylara Reis
Vasques, Enio Rodrigues
de Oliveira Alvim, Rafael
Mill, José Geraldo
Andreão, Rodrigo Varejão
Vasques, Bruna Kim
Pereira, Alexandre Costa
Krieger, Jose Eduardo
Age and Sex Differences in Heart Rate Variability and Vagal Specific Patterns – Baependi Heart Study
title Age and Sex Differences in Heart Rate Variability and Vagal Specific Patterns – Baependi Heart Study
title_full Age and Sex Differences in Heart Rate Variability and Vagal Specific Patterns – Baependi Heart Study
title_fullStr Age and Sex Differences in Heart Rate Variability and Vagal Specific Patterns – Baependi Heart Study
title_full_unstemmed Age and Sex Differences in Heart Rate Variability and Vagal Specific Patterns – Baependi Heart Study
title_short Age and Sex Differences in Heart Rate Variability and Vagal Specific Patterns – Baependi Heart Study
title_sort age and sex differences in heart rate variability and vagal specific patterns – baependi heart study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583712/
https://www.ncbi.nlm.nih.gov/pubmed/33150136
http://dx.doi.org/10.5334/gh.873
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