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Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture

Abdominal aortic aneurysm (AAA) rupture is an important cause of death in older adults. In clinical practice, the most established predictor of AAA rupture is maximum AAA diameter. Aortic diameter is commonly used to assess AAA severity in mouse models studies. AAA rupture occurs when the stress (fo...

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Autores principales: Murali Krishna, Smriti, Morton, Susan K., Li, Jiaze, Golledge, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583758/
https://www.ncbi.nlm.nih.gov/pubmed/33008131
http://dx.doi.org/10.3390/ijms21197250
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author Murali Krishna, Smriti
Morton, Susan K.
Li, Jiaze
Golledge, Jonathan
author_facet Murali Krishna, Smriti
Morton, Susan K.
Li, Jiaze
Golledge, Jonathan
author_sort Murali Krishna, Smriti
collection PubMed
description Abdominal aortic aneurysm (AAA) rupture is an important cause of death in older adults. In clinical practice, the most established predictor of AAA rupture is maximum AAA diameter. Aortic diameter is commonly used to assess AAA severity in mouse models studies. AAA rupture occurs when the stress (force per unit area) on the aneurysm wall exceeds wall strength. Previous research suggests that aortic wall structure and strength, biomechanical forces on the aorta and cellular and proteolytic composition of the AAA wall influence the risk of AAA rupture. Mouse models offer an opportunity to study the association of these factors with AAA rupture in a way not currently possible in patients. Such studies could provide data to support the use of novel surrogate markers of AAA rupture in patients. In this review, the currently available mouse models of AAA and their relevance to the study of AAA rupture are discussed. The review highlights the limitations of mouse models and suggests novel approaches that could be incorporated in future experimental AAA studies to generate clinically relevant results.
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spelling pubmed-75837582020-10-28 Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture Murali Krishna, Smriti Morton, Susan K. Li, Jiaze Golledge, Jonathan Int J Mol Sci Review Abdominal aortic aneurysm (AAA) rupture is an important cause of death in older adults. In clinical practice, the most established predictor of AAA rupture is maximum AAA diameter. Aortic diameter is commonly used to assess AAA severity in mouse models studies. AAA rupture occurs when the stress (force per unit area) on the aneurysm wall exceeds wall strength. Previous research suggests that aortic wall structure and strength, biomechanical forces on the aorta and cellular and proteolytic composition of the AAA wall influence the risk of AAA rupture. Mouse models offer an opportunity to study the association of these factors with AAA rupture in a way not currently possible in patients. Such studies could provide data to support the use of novel surrogate markers of AAA rupture in patients. In this review, the currently available mouse models of AAA and their relevance to the study of AAA rupture are discussed. The review highlights the limitations of mouse models and suggests novel approaches that could be incorporated in future experimental AAA studies to generate clinically relevant results. MDPI 2020-09-30 /pmc/articles/PMC7583758/ /pubmed/33008131 http://dx.doi.org/10.3390/ijms21197250 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Murali Krishna, Smriti
Morton, Susan K.
Li, Jiaze
Golledge, Jonathan
Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture
title Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture
title_full Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture
title_fullStr Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture
title_full_unstemmed Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture
title_short Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture
title_sort risk factors and mouse models of abdominal aortic aneurysm rupture
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583758/
https://www.ncbi.nlm.nih.gov/pubmed/33008131
http://dx.doi.org/10.3390/ijms21197250
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