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Cellular Prion Protein (PrPc): Putative Interacting Partners and Consequences of the Interaction

Cellular prion protein (PrPc) is a small glycosylphosphatidylinositol (GPI) anchored protein most abundantly found in the outer leaflet of the plasma membrane (PM) in the central nervous system (CNS). PrPc misfolding causes neurodegenerative prion diseases in the CNS. PrPc interacts with a wide rang...

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Autores principales: Miranzadeh Mahabadi, Hajar, Taghibiglou, Changiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583789/
https://www.ncbi.nlm.nih.gov/pubmed/32992764
http://dx.doi.org/10.3390/ijms21197058
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author Miranzadeh Mahabadi, Hajar
Taghibiglou, Changiz
author_facet Miranzadeh Mahabadi, Hajar
Taghibiglou, Changiz
author_sort Miranzadeh Mahabadi, Hajar
collection PubMed
description Cellular prion protein (PrPc) is a small glycosylphosphatidylinositol (GPI) anchored protein most abundantly found in the outer leaflet of the plasma membrane (PM) in the central nervous system (CNS). PrPc misfolding causes neurodegenerative prion diseases in the CNS. PrPc interacts with a wide range of protein partners because of the intrinsically disordered nature of the protein’s N-terminus. Numerous studies have attempted to decipher the physiological role of the prion protein by searching for proteins which interact with PrPc. Biochemical characteristics and biological functions both appear to be affected by interacting protein partners. The key challenge in identifying a potential interacting partner is to demonstrate that binding to a specific ligand is necessary for cellular physiological function or malfunction. In this review, we have summarized the intracellular and extracellular interacting partners of PrPc and potential consequences of their binding. We also briefly describe prion disease-related mutations at the end of this review.
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spelling pubmed-75837892020-10-28 Cellular Prion Protein (PrPc): Putative Interacting Partners and Consequences of the Interaction Miranzadeh Mahabadi, Hajar Taghibiglou, Changiz Int J Mol Sci Review Cellular prion protein (PrPc) is a small glycosylphosphatidylinositol (GPI) anchored protein most abundantly found in the outer leaflet of the plasma membrane (PM) in the central nervous system (CNS). PrPc misfolding causes neurodegenerative prion diseases in the CNS. PrPc interacts with a wide range of protein partners because of the intrinsically disordered nature of the protein’s N-terminus. Numerous studies have attempted to decipher the physiological role of the prion protein by searching for proteins which interact with PrPc. Biochemical characteristics and biological functions both appear to be affected by interacting protein partners. The key challenge in identifying a potential interacting partner is to demonstrate that binding to a specific ligand is necessary for cellular physiological function or malfunction. In this review, we have summarized the intracellular and extracellular interacting partners of PrPc and potential consequences of their binding. We also briefly describe prion disease-related mutations at the end of this review. MDPI 2020-09-25 /pmc/articles/PMC7583789/ /pubmed/32992764 http://dx.doi.org/10.3390/ijms21197058 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Miranzadeh Mahabadi, Hajar
Taghibiglou, Changiz
Cellular Prion Protein (PrPc): Putative Interacting Partners and Consequences of the Interaction
title Cellular Prion Protein (PrPc): Putative Interacting Partners and Consequences of the Interaction
title_full Cellular Prion Protein (PrPc): Putative Interacting Partners and Consequences of the Interaction
title_fullStr Cellular Prion Protein (PrPc): Putative Interacting Partners and Consequences of the Interaction
title_full_unstemmed Cellular Prion Protein (PrPc): Putative Interacting Partners and Consequences of the Interaction
title_short Cellular Prion Protein (PrPc): Putative Interacting Partners and Consequences of the Interaction
title_sort cellular prion protein (prpc): putative interacting partners and consequences of the interaction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583789/
https://www.ncbi.nlm.nih.gov/pubmed/32992764
http://dx.doi.org/10.3390/ijms21197058
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