Protective Effects of Simvastatin on Endotoxin-Induced Acute Kidney Injury through Activation of Tubular Epithelial Cells’ Survival and Hindering Cytochrome C-Mediated Apoptosis

Increasing evidence suggests that apoptosis of tubular cells and renal inflammation mainly determine the outcome of sepsis-associated acute kidney injury (AKI). The study aim was to investigate the molecular mechanism involved in the renoprotective effects of simvastatin in endotoxin (lipopolysaccha...

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Detalles Bibliográficos
Autores principales: Nežić, Lana, Škrbić, Ranko, Amidžić, Ljiljana, Gajanin, Radoslav, Milovanović, Zoran, Nepovimova, Eugenie, Kuča, Kamil, Jaćević, Vesna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583796/
https://www.ncbi.nlm.nih.gov/pubmed/33008033
http://dx.doi.org/10.3390/ijms21197236

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