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Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice

Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) cytokine family and an inflammation-associated protein. Here, we investigated the role of GDF15 in murine anti-glomerular basement membrane (GBM) glomerulonephritis. Glomerulonephritis induction in mice...

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Autores principales: Moschovaki-Filippidou, Foteini, Steiger, Stefanie, Lorenz, Georg, Schmaderer, Christoph, Ribeiro, Andrea, von Rauchhaupt, Ekaterina, Cohen, Clemens D., Anders, Hans-Joachim, Lindenmeyer, Maja, Lech, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583818/
https://www.ncbi.nlm.nih.gov/pubmed/32977372
http://dx.doi.org/10.3390/ijms21196978
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author Moschovaki-Filippidou, Foteini
Steiger, Stefanie
Lorenz, Georg
Schmaderer, Christoph
Ribeiro, Andrea
von Rauchhaupt, Ekaterina
Cohen, Clemens D.
Anders, Hans-Joachim
Lindenmeyer, Maja
Lech, Maciej
author_facet Moschovaki-Filippidou, Foteini
Steiger, Stefanie
Lorenz, Georg
Schmaderer, Christoph
Ribeiro, Andrea
von Rauchhaupt, Ekaterina
Cohen, Clemens D.
Anders, Hans-Joachim
Lindenmeyer, Maja
Lech, Maciej
author_sort Moschovaki-Filippidou, Foteini
collection PubMed
description Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) cytokine family and an inflammation-associated protein. Here, we investigated the role of GDF15 in murine anti-glomerular basement membrane (GBM) glomerulonephritis. Glomerulonephritis induction in mice induced systemic expression of GDF15. Moreover, we demonstrate the protective effects for GDF15, as GDF15-deficient mice exhibited increased proteinuria with an aggravated crescent formation and mesangial expansion in anti-GBM nephritis. Herein, GDF15 was required for the regulation of T-cell chemotactic chemokines in the kidney. In addition, we found the upregulation of the CXCR3 receptor in activated T-cells in GDF15-deficient mice. These data indicate that CXCL10/CXCR3-dependent-signaling promotes the infiltration of T cells into the organ during acute inflammation controlled by GDF15. Together, these results reveal a novel mechanism limiting the migration of lymphocytes to the site of inflammation during glomerulonephritis.
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spelling pubmed-75838182020-10-28 Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice Moschovaki-Filippidou, Foteini Steiger, Stefanie Lorenz, Georg Schmaderer, Christoph Ribeiro, Andrea von Rauchhaupt, Ekaterina Cohen, Clemens D. Anders, Hans-Joachim Lindenmeyer, Maja Lech, Maciej Int J Mol Sci Article Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) cytokine family and an inflammation-associated protein. Here, we investigated the role of GDF15 in murine anti-glomerular basement membrane (GBM) glomerulonephritis. Glomerulonephritis induction in mice induced systemic expression of GDF15. Moreover, we demonstrate the protective effects for GDF15, as GDF15-deficient mice exhibited increased proteinuria with an aggravated crescent formation and mesangial expansion in anti-GBM nephritis. Herein, GDF15 was required for the regulation of T-cell chemotactic chemokines in the kidney. In addition, we found the upregulation of the CXCR3 receptor in activated T-cells in GDF15-deficient mice. These data indicate that CXCL10/CXCR3-dependent-signaling promotes the infiltration of T cells into the organ during acute inflammation controlled by GDF15. Together, these results reveal a novel mechanism limiting the migration of lymphocytes to the site of inflammation during glomerulonephritis. MDPI 2020-09-23 /pmc/articles/PMC7583818/ /pubmed/32977372 http://dx.doi.org/10.3390/ijms21196978 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moschovaki-Filippidou, Foteini
Steiger, Stefanie
Lorenz, Georg
Schmaderer, Christoph
Ribeiro, Andrea
von Rauchhaupt, Ekaterina
Cohen, Clemens D.
Anders, Hans-Joachim
Lindenmeyer, Maja
Lech, Maciej
Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice
title Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice
title_full Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice
title_fullStr Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice
title_full_unstemmed Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice
title_short Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice
title_sort growth differentiation factor 15 ameliorates anti-glomerular basement membrane glomerulonephritis in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583818/
https://www.ncbi.nlm.nih.gov/pubmed/32977372
http://dx.doi.org/10.3390/ijms21196978
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