Cargando…

Inhibitory Effect of a Human MicroRNA, miR-6133-5p, on the Fibrotic Activity of Hepatic Stellate Cells in Culture

Background: We recently identified 39 human microRNAs, which effectively suppress hepatitis B virus (HBV) replication in hepatocytes. Chronic HBV infection often results in active, hepatitis-related liver fibrosis; hence, we assessed whether any of these microRNAs have anti-fibrotic potential and pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hamada-Tsutsumi, Susumu, Onishi, Masaya, Matsuura, Kentaro, Isogawa, Masanori, Kawashima, Keigo, Sato, Yusuke, Tanaka, Yasuhito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583928/ https://www.ncbi.nlm.nih.gov/pubmed/33019495 http://dx.doi.org/10.3390/ijms21197251

Ejemplares similares

Restoration of type I interferon signaling in intrahepatically primed CD8(+) T cells promotes functional differentiation
por: Kawashima, Keigo, et al.
Publicado: (2021)

Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen
por: Baudi, Ian, et al.
Publicado: (2021)

Screening of microRNAs for a repressor of hepatitis B virus replication
por: Naito, Yutaka, et al.
Publicado: (2018)

HBV-Specific CD8+ T-Cell Tolerance in the Liver
por: Baudi, Ian, et al.
Publicado: (2021)

MicroRNA and liver cancer
por: Onishi, Masaya, et al.
Publicado: (2020)

Validation of Cross-Genotype Neutralization by Hepatitis B Virus-Specific Monoclonal Antibodies by In Vitro and In Vivo Infection
por: Hamada-Tsutsumi, Susumu, et al.
Publicado: (2015)

Anti-fibrotic effects of phenolic compounds on pancreatic stellate cells
por: Lin, Zesi, et al.
Publicado: (2015)

Droplet digital PCR assay provides intrahepatic HBV cccDNA quantification tool for clinical application
por: Hayashi, Sanae, et al.
Publicado: (2022)

Synergistic MicroRNA Therapy in Liver Fibrotic Rat Using MRI‐Visible Nanocarrier Targeting Hepatic Stellate Cells
por: Wu, Jun, et al.
Publicado: (2019)

PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells
por: Rady, Brian, et al.
Publicado: (2021)

Anti-fibrotic effects of branched-chain amino acids on hepatic stellate cells
por: Lee, Hae Lim, et al.
Publicado: (2022)

Circulating let-7 Levels in Serum Correlate With the Severity of Hepatic Fibrosis in Chronic Hepatitis C
por: Matsuura, Kentaro, et al.
Publicado: (2018)

Data on the effect of pro-fibrotic cytokine TGF-β on hepatic stellate cell autophagy
por: Thomes, Paul G., et al.
Publicado: (2016)

Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model
por: Kim, In Hee, et al.
Publicado: (2012)

Extracellular Vesicles from Steatotic Hepatocytes Provoke Pro-Fibrotic Responses in Cultured Stellate Cells
por: Koenen, Maria Teresa, et al.
Publicado: (2022)

Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic Treatment of Non-Alcoholic Fatty Liver Disease
por: Kimura, Takefumi, et al.
Publicado: (2021)

Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells
por: Hicks, Daniel F., et al.
Publicado: (2017)

Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells
por: Lee, Young-Sun, et al.
Publicado: (2017)

Pharmacological Inhibition of Cyclin-Dependent Kinases Triggers Anti-Fibrotic Effects in Hepatic Stellate Cells In Vitro
por: Hübbers, Anna, et al.
Publicado: (2020)

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
por: Min, Kyounghee, et al.
Publicado: (2023)

Inhibitory Effect of Tanshinone IIA on Rat Hepatic Stellate Cells
por: Liu, Ya-Wei, et al.
Publicado: (2014)

sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH
por: Hall, Katherine C., et al.
Publicado: (2019)

Selective phytochemicals targeting pancreatic stellate cells as new anti-fibrotic agents for chronic pancreatitis and pancreatic cancer
por: Ramakrishnan, Puvanesswaray, et al.
Publicado: (2020)

Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus
por: Ngodup, Tenzin, et al.
Publicado: (2020)

Islet Stellate Cells Isolated from Fibrotic Islet of Goto-Kakizaki Rats Affect Biological Behavior of Beta-Cell
por: Li, Feng-Fei, et al.
Publicado: (2016)

Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation
por: Wilhelm, Annika, et al.
Publicado: (2016)

Anti-fibrotic effects of Orostachys japonicus A. Berger (Crassulaceae) on hepatic stellate cells and thioacetamide-induced fibrosis in rats
por: Koppula, Sushruta, et al.
Publicado: (2017)

Anti-fibrotic effects of Cuscuta chinensis with in vitro hepatic stellate cells and a thioacetamide-induced experimental rat model
por: Kim, Jin Seoub, et al.
Publicado: (2017)

AMP‐activated protein kinase regulates lipid metabolism and the fibrotic phenotype of hepatic stellate cells through inhibition of autophagy
por: Chen, Ming, et al.
Publicado: (2017)

Targeting Activated Hepatic Stellate Cells Using Collagen-Binding Chitosan Nanoparticles for siRNA Delivery to Fibrotic Livers
por: Azzam, Menna, et al.
Publicado: (2020)

Human Liver Stem Cell-Derived Extracellular Vesicles Target Hepatic Stellate Cells and Attenuate Their Pro-fibrotic Phenotype
por: Chiabotto, Giulia, et al.
Publicado: (2021)

Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells
por: Li, Wenyang, et al.
Publicado: (2022)

Anti-fibrotic effect of extracellular vesicles derived from tea leaves in hepatic stellate cells and liver fibrosis mice
por: Gong, Qianyuan, et al.
Publicado: (2022)

Secretome of senescent hepatic stellate cells favors malignant transformation from nonalcoholic steatohepatitis-fibrotic progression to hepatocellular carcinoma
por: Zhou, Yuan, et al.
Publicado: (2023)

Generation of Fibrotic Liver Organoids Using Hepatocytes, Primary Liver Sinusoidal Endothelial Cells, Hepatic Stellate Cells, and Macrophages
por: Yoon, Yongdae, et al.
Publicado: (2023)

Anti-Fibrotic Effects of DL-Glyceraldehyde in Hepatic Stellate Cells via Activation of ERK-JNK-Caspase-3 Signaling Axis
por: Samsuzzaman, Md., et al.
Publicado: (2023)

Pancreatic carcinoma metastasis to a lung carcinoma lesion and pulmonary fibrotic regions, overtaking the stromal microenvironment: A case report
por: Nakaya, Takeo, et al.
Publicado: (2019)

The inhibitory effect of TU-100 on hepatic stellate cell activation in the tumor microenvironment
por: Wada, Yuma, et al.
Publicado: (2020)

Pancreatic Stellate Cells and Metabolic Alteration: Physiology and Pathophysiology
por: Hamada, Shin, et al.
Publicado: (2022)

Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis
por: Kitano, Mio, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_mgqe9j8thsbsckf26vo75d2mpr