Cargando…

Chrysin Inhibits NF-κB-Dependent CCL5 Transcription by Targeting IκB Kinase in the Atopic Dermatitis-Like Inflammatory Microenvironment

Chrysin (5,7-dihydroxyflavone) is a natural polyphenolic compound that induces an anti-inflammatory response. In this study, we investigated the molecular mechanism underlying the chrysin-induced suppression of C-C motif chemokine ligand 5 (CCL5) gene expression in atopic dermatitis (AD)-like inflam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yeo, Hyunjin, Lee, Young Han, Koh, Dongsoo, Lim, Yoongho, Shin, Soon Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583951/ https://www.ncbi.nlm.nih.gov/pubmed/33027922 http://dx.doi.org/10.3390/ijms21197348

Ejemplares similares

Chrysin Inhibits TNFα-Induced TSLP Expression through Downregulation of EGR1 Expression in Keratinocytes
por: Yeo, Hyunjin, et al.
Publicado: (2021)

β-Caryophyllene Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis through the Downregulation of Mitogen-Activated Protein Kinase/EGR1/TSLP Signaling Axis
por: Ahn, Sung Shin, et al.
Publicado: (2022)

(-)-α-Bisabolol Alleviates Atopic Dermatitis by Inhibiting MAPK and NF-κB Signaling in Mast Cell
por: Li, Guangxia, et al.
Publicado: (2022)

A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-κB pathway in BV2 microglial cells
por: Lee, Young Han, et al.
Publicado: (2012)

Use of a Silkworm (Bombyx mori) Larvae By-Product for the Treatment of Atopic Dermatitis: Inhibition of NF-κB Nuclear Translocation and MAPK Signaling
por: Fan, Meiqi, et al.
Publicado: (2023)

Disulfide-Mediated Stabilization of the IκB Kinase Binding Domain of NF-κB Essential Modulator (NEMO)
por: Zhou, Li, et al.
Publicado: (2014)

Caffeoyl-Prolyl-Histidine Amide Inhibits Fyn and Alleviates Atopic Dermatitis-Like Phenotypes via Suppression of NF-κB Activation
por: Jeong, Hayan, et al.
Publicado: (2020)

Beyond NF-κB activation: nuclear functions of IκB kinase α
por: Huang, Wei-Chien, et al.
Publicado: (2013)

Crocin Ameliorates Atopic Dermatitis Symptoms by down Regulation of Th2 Response via Blocking of NF-κB/STAT6 Signaling Pathways in Mice
por: Sung, Yoon-Young, et al.
Publicado: (2018)

Inhibitory-κB Kinase (IKK) α and Nuclear Factor-κB (NFκB)-Inducing Kinase (NIK) as Anti-Cancer Drug Targets
por: Paul, Andrew, et al.
Publicado: (2018)

Impressic Acid Ameliorates Atopic Dermatitis-Like Skin Lesions by Inhibiting ERK1/2-Mediated Phosphorylation of NF-κB and STAT1
por: Choi, Jae Ho, et al.
Publicado: (2021)

The UPR inducer DPP23 inhibits the metastatic potential of MDA-MB-231 human breast cancer cells by targeting the Akt–IKK–NF-κB–MMP-9 axis
por: Shin, Soon Young, et al.
Publicado: (2016)

Inhibitory Effect of Alisma canaliculatum Ethanolic Extract on NF-κB-Dependent CXCR3 and CXCL10 Expression in TNFα-Exposed MDA-MB-231 Breast Cancer Cells
por: Choi, Jihye, et al.
Publicado: (2018)

Expression of CYLD and NF-κB in Human Cholesteatoma Epithelium
por: Byun, Jae Yong, et al.
Publicado: (2010)

KIAA1549-BRAF Expression Establishes a Permissive Tumor Microenvironment Through NFκB-Mediated CCL2 Production
por: Chen, Ran, et al.
Publicado: (2018)

Chronic Proliferative Dermatitis in Mice: NFκB Activation Autoinflammatory Disease
por: Liang, Yanhua
Publicado: (2011)

Chrysin Attenuates VCAM-1 Expression and Monocyte Adhesion in Lipopolysaccharide-Stimulated Brain Endothelial Cells by Preventing NF-κB Signaling
por: Lee, Bo Kyung, et al.
Publicado: (2017)

Chrysin Protects Against Titanium Particle-Induced Osteolysis by Attenuating Osteoclast Formation and Function by Inhibiting NF-κB and MAPK Signaling
por: Wu, Zuoxing, et al.
Publicado: (2022)

Essential Role of Nuclear Factor (NF)-κB–Inducing Kinase and Inhibitor of κb (Iκb) Kinase α in Nf-κb Activation through Lymphotoxin β Receptor, but Not through Tumor Necrosis Factor Receptor I
por: Matsushima, Akemi, et al.
Publicado: (2001)

Anisomycin protects against sepsis by attenuating IκB kinase-dependent NF-κB activation and inflammatory gene expression
por: Park, Gyoung Lim, et al.
Publicado: (2021)

Peripheral NF-κB dysregulation in people with schizophrenia drives inflammation: putative anti-inflammatory functions of NF-κB kinases
por: Murphy, Caitlin E., et al.
Publicado: (2022)

Lirioresinol B dimethyl ether inhibits NF-κB and COX-2 and activates IκBα expression in CCl(4)-induced hepatic fibrosis
por: Shehzad, Adeeb, et al.
Publicado: (2020)

Hepatic NF‐κB‐Inducing Kinase and Inhibitor of NF‐κB Kinase Subunit α Promote Liver Oxidative Stress, Ferroptosis, and Liver Injury
por: Zhong, Xiao, et al.
Publicado: (2021)

Anti-Atopic Dermatitis Effect of TPS240, a Novel Therapeutic Peptide, via Suppression of NF-κB and STAT3 Activation
por: Lee, Dongwoo, et al.
Publicado: (2023)

NF-κB and Disease
por: Poma, Paola
Publicado: (2020)

NF-κB and the Immunoglobulin κ Gene Enhancer
por: Sen, Ranjan
Publicado: (2004)

NF-κB Members Left Home: NF-κB-Independent Roles in Cancer
por: Colomer, Carlota, et al.
Publicado: (2017)

Regulation of IκBα expression involves both NF-κB and the MAP kinase signaling pathways
por: Zhang, Ning, et al.
Publicado: (2005)

EV-Mediated Chemoresistance in the Tumor Microenvironment: Is NF-κB a Player?
por: Di Vito Nolfi, Mauro, et al.
Publicado: (2022)

NF-κB mediated regulation of tumor cell proliferation in hypoxic microenvironment
por: Rastogi, Shubham, et al.
Publicado: (2023)

The Tumor Suppressor, p53, Negatively Regulates Non-Canonical NF-κB Signaling through miRNA-Induced Silencing of NF-κB–Inducing Kinase
por: Jang, Hanbit, et al.
Publicado: (2020)

Analysis of variation in NF-κB genes and expression levels of NF-κB-regulated molecules
por: Liu-Mares, Wen, et al.
Publicado: (2007)

Gentiopicroside ameliorates CCl(4)-induced liver injury in mice by regulating the PPAR-γ/Nrf2 and NF-κB/IκB signaling pathways
por: Zhang, Yun, et al.
Publicado: (2023)

NFκB regulates expression of Polo-like kinase 4
por: Ledoux, Adeline C, et al.
Publicado: (2013)

NF-κB Inducing Kinase Regulates Intestinal Immunity and Homeostasis
por: Wang, Bingran, et al.
Publicado: (2022)

NF-κB Inducing Kinase, a Central Signaling Component of the Non-Canonical Pathway of NF-κB, Contributes to Ovarian Cancer Progression
por: Uno, Masaya, et al.
Publicado: (2014)

NF-κB1 p105 suppresses lung tumorigenesis through the Tpl2 kinase but independently of its NF-κB function
por: Sun, Fan, et al.
Publicado: (2015)

Correction: A Novel NF-κB-inducing Kinase-MAPK Signaling Pathway Up-regulates NF-κB Activity in Melanoma Cells
por: Dhawan, Punita, et al.
Publicado: (2022)

NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma
por: Jayawant, Eleanor, et al.
Publicado: (2023)

I-κB kinase-ε deficiency improves doxorubicin-induced dilated cardiomyopathy by inhibiting the NF-κB pathway
por: Liu, Yafeng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ku41mome1evvnt3agbdurmp29u