Development and Validation of an LC-MS/MS Assay to Quantitate 2′,4′,6′-Trihydroxyacetophenone in Rat and Dog Plasma and its Application to a Pharmacokinetic Study

In the present study, a simple, rapid, and reliable bioanalytical method was developed using liquid chromatography with tandem-mass spectrometry (LC-MS/MS) to quantify 2′,4′,6′-trihydroxyacetophenone (THAP) in rat and dog plasma with 2′,4′,6′-trihydroxybenzaldehyde as an internal standard (IS). The...

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Detalles Bibliográficos
Autores principales: Yoo, Hee Jo, Hwang, Se-Jung, Lee, Jeong-Hun, Shim, Wang-Seob, Choi, Yun-Woong, Cho, Sang Min, Chung, Eun Kyoung, Park, Jun-Bom, Lee, Kyung-Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583961/
https://www.ncbi.nlm.nih.gov/pubmed/32977631
http://dx.doi.org/10.3390/molecules25194373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583961/
https://www.ncbi.nlm.nih.gov/pubmed/32977631
http://dx.doi.org/10.3390/molecules25194373

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