Cargando…

Development and Validation of an LC-MS/MS Assay to Quantitate 2′,4′,6′-Trihydroxyacetophenone in Rat and Dog Plasma and its Application to a Pharmacokinetic Study

In the present study, a simple, rapid, and reliable bioanalytical method was developed using liquid chromatography with tandem-mass spectrometry (LC-MS/MS) to quantify 2′,4′,6′-trihydroxyacetophenone (THAP) in rat and dog plasma with 2′,4′,6′-trihydroxybenzaldehyde as an internal standard (IS). The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoo, Hee Jo, Hwang, Se-Jung, Lee, Jeong-Hun, Shim, Wang-Seob, Choi, Yun-Woong, Cho, Sang Min, Chung, Eun Kyoung, Park, Jun-Bom, Lee, Kyung-Tae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583961/ https://www.ncbi.nlm.nih.gov/pubmed/32977631 http://dx.doi.org/10.3390/molecules25194373

Ejemplares similares

A Validated Chiral LC–MS/MS Method for the Enantioselective Determination of (S)-(+)- and (R)-(-)-Ibuprofen in Dog Plasma: Its Application to a Pharmacokinetic Study
por: Choi, Sanghee, et al.
Publicado: (2023)

A Pharmacokinetic Study of Ephedrine and Pseudoephedrine after Oral Administration of Ojeok-San by Validated LC-MS/MS Method in Human Plasma
por: Lee, Sooyoung, et al.
Publicado: (2021)

Largazole Pharmacokinetics in Rats by LC-MS/MS
por: Yu, Mingming, et al.
Publicado: (2014)

Non-Steroidal Drug Interferences in a Quantitative Multisteroid LC-MS/MS Assay
por: Braun, Valentin, et al.
Publicado: (2023)

LC–MS/MS assay for quantitation of enalapril and enalaprilat in plasma for bioequivalence study in Indian subjects
por: Halder, Dhiman, et al.
Publicado: (2017)

Development of an LC–MS/MS method for the quantitation of deoxyglycychloxazol in rat plasma and its application in pharmacokinetic study()
por: Li, Rongshan, et al.
Publicado: (2016)

Development of an LC–MS/MS Assay and Toxicokinetic Characterization of Hexamethylenetetramine in Rats
por: Kim, Woojin, et al.
Publicado: (2023)

Optimization of the CYP inhibition assay using LC-MS/MS
por: Abduraman, Muhammad Asyraf, et al.
Publicado: (2022)

Effects of triptolide on pharmacokinetics of amlodipine in rats by using LC–MS/MS
por: Zhang, Chengyin, et al.
Publicado: (2018)

Determination and pharmacokinetics study of oxyclozanide suspension in cattle by LC-MS/MS
por: Zhang, Jili, et al.
Publicado: (2019)

LC–MS/MS method for the quantitation of decitabine and venetoclax in rat plasma after SPE: Application to pharmacokinetic study
por: Alnasser, Abdulaziz I., et al.
Publicado: (2023)

Quantitation of cyclic dinucleotides by reversed-phase LC-MS/MS
por: Spangler, Christian, et al.
Publicado: (2009)

Quantitation of Apremilast in Beagle Dogs Plasma by UPLC-MS-MS and Its Application to Pharmacokinetic Studies
por: Xiong, Wei, et al.
Publicado: (2021)

LC–MS/MS assay for the determination of natamycin in rabbit and human plasma: Application to a pharmacokinetics and protein binding study
por: Chhonker, Yashpal Singh, et al.
Publicado: (2013)

Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MS/MS
por: Xu, Dan, et al.
Publicado: (2020)

Determination and pharmacokinetics study of UK-5099 in mouse plasma by LC–MS/MS
por: Zeng, Qingyuan, et al.
Publicado: (2022)

Evaluation of In Vivo Prepared Albumin-Drug Conjugate Using Immunoprecipitation Linked LC-MS Assay and Its Application to Mouse Pharmacokinetic Study
por: Lim, Jeong-Hyeon, et al.
Publicado: (2023)

Quantitative determination of D(4)-cystine in mice using LC-MS/MS and its application to the assessment of pharmacokinetics and bioavailability
por: Li, Shuning, et al.
Publicado: (2021)

Development of a Rapid LC-MS/MS Method for Simultaneous Quantification of Donepezil and Tadalafil in Rat Plasma: Its Application in a Pharmacokinetic Interaction Study after Oral Administration in Rats
por: Yoon, Jiyoung, et al.
Publicado: (2023)

Development of an UPLC-MS/MS Method for the Quantitative Analysis of Upadacitinib in Beagle Dog Plasma and Pharmacokinetics Study
por: Wang, Meng-Jie, et al.
Publicado: (2021)

Identification and Pharmacokinetic Studies on Complanatuside and Its Major Metabolites in Rats by UHPLC-Q-TOF-MS/MS and LC-MS/MS
por: Yao, Yu-Feng, et al.
Publicado: (2018)

Development and validation of a LC–MS/MS method for quantification of hetrombopag for pharmacokinetics study
por: Chen, Tao, et al.
Publicado: (2015)

Quantification of tolvaptan in rabbit plasma by LC–MS/MS: Application to a pharmacokinetic study()
por: Moola, Kumar S., et al.
Publicado: (2015)

The LC-MS/MS-Based Measurement of Isopimaric Acid in Rat Plasma and Application of Pharmacokinetics
por: Huang, Doudou, et al.
Publicado: (2021)

LC-MS/MS Method for Determination of Hydroxychloroquine and Metabolites: Application in a Pharmacokinetic Study
por: Cui, Lili, et al.
Publicado: (2022)

Quantitation of bivalirudin, a novel anticoagulant peptide, in human plasma by LC–MS/MS: Method development, validation and application to pharmacokinetics
por: Li, Xiao-Jiao, et al.
Publicado: (2013)

Pharmacokinetics of Nafamostat, a Potent Serine Protease Inhibitor, by a Novel LC-MS/MS Analysis
por: Oh, Hyeon Seok, et al.
Publicado: (2022)

Analytical Method Development of Benzisothiazolinone, a Biocide, Using LC–MS/MS and a Pharmacokinetic Application in Rat Biological Matrices
por: Jo, Seong Jun, et al.
Publicado: (2023)

A quick and simple method for the determination of ivermectin in dog plasma by LC–MS/MS
por: Morbidelli, Eva, et al.
Publicado: (2018)

An LC–MS/MS method for the determination of budesonide and 16α-hydroxyprednisolone in dog plasma
por: Gazzotti, Teresa, et al.
Publicado: (2016)

Quantitative LC-MS/MS Analysis of Proteins Involved in Metastasis of Breast Cancer
por: Goto, Rieko, et al.
Publicado: (2015)

Dataset of mouse hippocampus profiled by LC–MS/MS for label-free quantitation
por: English, Jane A., et al.
Publicado: (2016)

Application of LC–MS/MS for quantitative analysis of glucocorticoids and stimulants in biological fluids
por: Haneef, Jamshed, et al.
Publicado: (2013)

Quantitative LC–MS/MS uncovers the regulatory role of autophagy in immune thrombocytopenia
por: Sun, Rui-Jie, et al.
Publicado: (2021)

Bioavailable Sulforaphane Quantitation in Plasma by LC–MS/MS Is Enhanced by Blocking Thiols
por: Grady, Rachel S., et al.
Publicado: (2023)

LC, MS(n) and LC–MS/MS studies for the characterization of degradation products of amlodipine
por: Tiwari, Ravi N., et al.
Publicado: (2015)

Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice
por: Kumar, Vinod, et al.
Publicado: (2018)

Simultaneous Determination of Atorvastatin and Aspirin in Human Plasma by LC–MS/MS: Its Pharmacokinetic Application
por: Gajula, Ramakrishna, et al.
Publicado: (2012)

Pharmacokinetics and Bioequivalence Study of Hydroxychloroquine Sulfate Tablets in Chinese Healthy Volunteers by LC–MS/MS
por: Fan, Hong-wei, et al.
Publicado: (2015)

Bioanalytical Method for Carbocisteine in Human Plasma by Using LC-MS/MS: A Pharmacokinetic Application
por: Dhanure, Shivanand, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_7boadnhrfjf6t3ebb29lnip1mr