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The Role of microRNAs in Epithelial Ovarian Cancer Metastasis
Epithelial ovarian cancer (EOC) is the deadliest gynecological cancer, and the major cause of death is mainly attributed to metastasis. MicroRNAs (miRNAs) are a group of small non-coding RNAs that exert important regulatory functions in many biological processes through their effects on regulating g...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583982/ https://www.ncbi.nlm.nih.gov/pubmed/32993038 http://dx.doi.org/10.3390/ijms21197093 |
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author | Nguyen, Vu Hong Loan Yue, Chenyang Du, Kevin Y. Salem, Mohamed O’Brien, Jacob Peng, Chun |
author_facet | Nguyen, Vu Hong Loan Yue, Chenyang Du, Kevin Y. Salem, Mohamed O’Brien, Jacob Peng, Chun |
author_sort | Nguyen, Vu Hong Loan |
collection | PubMed |
description | Epithelial ovarian cancer (EOC) is the deadliest gynecological cancer, and the major cause of death is mainly attributed to metastasis. MicroRNAs (miRNAs) are a group of small non-coding RNAs that exert important regulatory functions in many biological processes through their effects on regulating gene expression. In most cases, miRNAs interact with the 3′ UTRs of target mRNAs to induce their degradation and suppress their translation. Aberrant expression of miRNAs has been detected in EOC tumors and/or the biological fluids of EOC patients. Such dysregulation occurs as the result of alterations in DNA copy numbers, epigenetic regulation, and miRNA biogenesis. Many studies have demonstrated that miRNAs can promote or suppress events related to EOC metastasis, such as cell migration, invasion, epithelial-to-mesenchymal transition, and interaction with the tumor microenvironment. In this review, we provide a brief overview of miRNA biogenesis and highlight some key events and regulations related to EOC metastasis. We summarize current knowledge on how miRNAs are dysregulated, focusing on those that have been reported to regulate metastasis. Furthermore, we discuss the role of miRNAs in promoting and inhibiting EOC metastasis. Finally, we point out some limitations of current findings and suggest future research directions in the field. |
format | Online Article Text |
id | pubmed-7583982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75839822020-10-29 The Role of microRNAs in Epithelial Ovarian Cancer Metastasis Nguyen, Vu Hong Loan Yue, Chenyang Du, Kevin Y. Salem, Mohamed O’Brien, Jacob Peng, Chun Int J Mol Sci Review Epithelial ovarian cancer (EOC) is the deadliest gynecological cancer, and the major cause of death is mainly attributed to metastasis. MicroRNAs (miRNAs) are a group of small non-coding RNAs that exert important regulatory functions in many biological processes through their effects on regulating gene expression. In most cases, miRNAs interact with the 3′ UTRs of target mRNAs to induce their degradation and suppress their translation. Aberrant expression of miRNAs has been detected in EOC tumors and/or the biological fluids of EOC patients. Such dysregulation occurs as the result of alterations in DNA copy numbers, epigenetic regulation, and miRNA biogenesis. Many studies have demonstrated that miRNAs can promote or suppress events related to EOC metastasis, such as cell migration, invasion, epithelial-to-mesenchymal transition, and interaction with the tumor microenvironment. In this review, we provide a brief overview of miRNA biogenesis and highlight some key events and regulations related to EOC metastasis. We summarize current knowledge on how miRNAs are dysregulated, focusing on those that have been reported to regulate metastasis. Furthermore, we discuss the role of miRNAs in promoting and inhibiting EOC metastasis. Finally, we point out some limitations of current findings and suggest future research directions in the field. MDPI 2020-09-25 /pmc/articles/PMC7583982/ /pubmed/32993038 http://dx.doi.org/10.3390/ijms21197093 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nguyen, Vu Hong Loan Yue, Chenyang Du, Kevin Y. Salem, Mohamed O’Brien, Jacob Peng, Chun The Role of microRNAs in Epithelial Ovarian Cancer Metastasis |
title | The Role of microRNAs in Epithelial Ovarian Cancer Metastasis |
title_full | The Role of microRNAs in Epithelial Ovarian Cancer Metastasis |
title_fullStr | The Role of microRNAs in Epithelial Ovarian Cancer Metastasis |
title_full_unstemmed | The Role of microRNAs in Epithelial Ovarian Cancer Metastasis |
title_short | The Role of microRNAs in Epithelial Ovarian Cancer Metastasis |
title_sort | role of micrornas in epithelial ovarian cancer metastasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583982/ https://www.ncbi.nlm.nih.gov/pubmed/32993038 http://dx.doi.org/10.3390/ijms21197093 |
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