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The Role and Impact of Extracellular Vesicles in the Modulation and Delivery of Cytokines during Autoimmunity

Cytokines and extracellular vesicles are two methods of initiating and maintaining cellular crosstalk. The role of cytokines in the initiation, progression, and resolution of inflammation has been well studied and more so, their pathophysiological role in the development of autoimmune disease. In re...

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Autores principales: Hussain, Mohammed Tayab, Iqbal, Asif Jilani, Norling, Lucy Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584003/
https://www.ncbi.nlm.nih.gov/pubmed/32993051
http://dx.doi.org/10.3390/ijms21197096
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author Hussain, Mohammed Tayab
Iqbal, Asif Jilani
Norling, Lucy Victoria
author_facet Hussain, Mohammed Tayab
Iqbal, Asif Jilani
Norling, Lucy Victoria
author_sort Hussain, Mohammed Tayab
collection PubMed
description Cytokines and extracellular vesicles are two methods of initiating and maintaining cellular crosstalk. The role of cytokines in the initiation, progression, and resolution of inflammation has been well studied and more so, their pathophysiological role in the development of autoimmune disease. In recent years, the impact of extracellular vesicles on the progression of autoimmunity has become more widely appreciated. In this review, we discuss the mechanisms that allow extracellular vesicles of various sources to modulate cytokine production, and release, and how extracellular vesicles might be involved in the direct delivery and modulation of cytokine levels. Moreover, we explore what challenges are faced by current therapies and the promising future for extracellular vesicles as therapeutic agents in conditions driven by immune dysregulation.
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spelling pubmed-75840032020-10-29 The Role and Impact of Extracellular Vesicles in the Modulation and Delivery of Cytokines during Autoimmunity Hussain, Mohammed Tayab Iqbal, Asif Jilani Norling, Lucy Victoria Int J Mol Sci Review Cytokines and extracellular vesicles are two methods of initiating and maintaining cellular crosstalk. The role of cytokines in the initiation, progression, and resolution of inflammation has been well studied and more so, their pathophysiological role in the development of autoimmune disease. In recent years, the impact of extracellular vesicles on the progression of autoimmunity has become more widely appreciated. In this review, we discuss the mechanisms that allow extracellular vesicles of various sources to modulate cytokine production, and release, and how extracellular vesicles might be involved in the direct delivery and modulation of cytokine levels. Moreover, we explore what challenges are faced by current therapies and the promising future for extracellular vesicles as therapeutic agents in conditions driven by immune dysregulation. MDPI 2020-09-26 /pmc/articles/PMC7584003/ /pubmed/32993051 http://dx.doi.org/10.3390/ijms21197096 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hussain, Mohammed Tayab
Iqbal, Asif Jilani
Norling, Lucy Victoria
The Role and Impact of Extracellular Vesicles in the Modulation and Delivery of Cytokines during Autoimmunity
title The Role and Impact of Extracellular Vesicles in the Modulation and Delivery of Cytokines during Autoimmunity
title_full The Role and Impact of Extracellular Vesicles in the Modulation and Delivery of Cytokines during Autoimmunity
title_fullStr The Role and Impact of Extracellular Vesicles in the Modulation and Delivery of Cytokines during Autoimmunity
title_full_unstemmed The Role and Impact of Extracellular Vesicles in the Modulation and Delivery of Cytokines during Autoimmunity
title_short The Role and Impact of Extracellular Vesicles in the Modulation and Delivery of Cytokines during Autoimmunity
title_sort role and impact of extracellular vesicles in the modulation and delivery of cytokines during autoimmunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584003/
https://www.ncbi.nlm.nih.gov/pubmed/32993051
http://dx.doi.org/10.3390/ijms21197096
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