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Cardio-renal and cardio-hepatic interactions predict cardiovascular events in elderly patients with heart failure

BACKGROUND: The composite Model for End-Stage Liver Disease Excluding International Normalized Ratio Score (MELD-XI) is a novel tool to evaluate cardio-renal and cardio-hepatic interactions in patients with advanced heart failure (HF). However, its prognostic ability remains unclear in elderly HF pa...

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Autores principales: Okano, Takahiro, Motoki, Hirohiko, Minamisawa, Masatoshi, Kimura, Kazuhiro, Kanai, Masafumi, Yoshie, Koji, Higuchi, Satoko, Saigusa, Tatsuya, Ebisawa, Soichiro, Okada, Ayako, Shoda, Morio, Kuwahara, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584193/
https://www.ncbi.nlm.nih.gov/pubmed/33095810
http://dx.doi.org/10.1371/journal.pone.0241003
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author Okano, Takahiro
Motoki, Hirohiko
Minamisawa, Masatoshi
Kimura, Kazuhiro
Kanai, Masafumi
Yoshie, Koji
Higuchi, Satoko
Saigusa, Tatsuya
Ebisawa, Soichiro
Okada, Ayako
Shoda, Morio
Kuwahara, Koichiro
author_facet Okano, Takahiro
Motoki, Hirohiko
Minamisawa, Masatoshi
Kimura, Kazuhiro
Kanai, Masafumi
Yoshie, Koji
Higuchi, Satoko
Saigusa, Tatsuya
Ebisawa, Soichiro
Okada, Ayako
Shoda, Morio
Kuwahara, Koichiro
author_sort Okano, Takahiro
collection PubMed
description BACKGROUND: The composite Model for End-Stage Liver Disease Excluding International Normalized Ratio Score (MELD-XI) is a novel tool to evaluate cardio-renal and cardio-hepatic interactions in patients with advanced heart failure (HF). However, its prognostic ability remains unclear in elderly HF patients. METHODS AND RESULTS: From July 2014 to July 2018, patients hospitalized for HF were prospectively recruited at 16 centers. Clinical features, laboratory findings, and echocardiography results were assessed prior to discharge. Cardiovascular (CV) death and HF re-hospitalization were recorded. Of the 676 patients enrolled, 264 (39.1%) experienced CV events throughout a 1-year median follow-up period. Patients with high MELD-XI were predominantly male and had a higher prevalence of NYHA III/IV, history of HF admission, hyperuricemia, ventricular tachycardia, anemia, and ischemic heart disease. In Kaplan-Meyer analysis, patients with higher MELD-XI (≥11) scores showed a worse prognosis than did those with lower (<11) scores (log-rank p≤0.001). Multivariate Cox proportional hazards testing revealed MELD-XI as an independent predictor of CV events (HR: 1.033, 95% CI: 1.006–1.061, p = 0.015) after adjusting for age, gender, body mass index, NYHA III/IV, prior HF hospitalization, systolic blood pressure, ischemic etiology, ventricular tachycardia, anemia, BNP, and left ventricular ejection fraction. CONCLUSIONS: Cardio-renal and cardio-hepatic interactions predicted CV events in aged HF patients.
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spelling pubmed-75841932020-10-27 Cardio-renal and cardio-hepatic interactions predict cardiovascular events in elderly patients with heart failure Okano, Takahiro Motoki, Hirohiko Minamisawa, Masatoshi Kimura, Kazuhiro Kanai, Masafumi Yoshie, Koji Higuchi, Satoko Saigusa, Tatsuya Ebisawa, Soichiro Okada, Ayako Shoda, Morio Kuwahara, Koichiro PLoS One Research Article BACKGROUND: The composite Model for End-Stage Liver Disease Excluding International Normalized Ratio Score (MELD-XI) is a novel tool to evaluate cardio-renal and cardio-hepatic interactions in patients with advanced heart failure (HF). However, its prognostic ability remains unclear in elderly HF patients. METHODS AND RESULTS: From July 2014 to July 2018, patients hospitalized for HF were prospectively recruited at 16 centers. Clinical features, laboratory findings, and echocardiography results were assessed prior to discharge. Cardiovascular (CV) death and HF re-hospitalization were recorded. Of the 676 patients enrolled, 264 (39.1%) experienced CV events throughout a 1-year median follow-up period. Patients with high MELD-XI were predominantly male and had a higher prevalence of NYHA III/IV, history of HF admission, hyperuricemia, ventricular tachycardia, anemia, and ischemic heart disease. In Kaplan-Meyer analysis, patients with higher MELD-XI (≥11) scores showed a worse prognosis than did those with lower (<11) scores (log-rank p≤0.001). Multivariate Cox proportional hazards testing revealed MELD-XI as an independent predictor of CV events (HR: 1.033, 95% CI: 1.006–1.061, p = 0.015) after adjusting for age, gender, body mass index, NYHA III/IV, prior HF hospitalization, systolic blood pressure, ischemic etiology, ventricular tachycardia, anemia, BNP, and left ventricular ejection fraction. CONCLUSIONS: Cardio-renal and cardio-hepatic interactions predicted CV events in aged HF patients. Public Library of Science 2020-10-23 /pmc/articles/PMC7584193/ /pubmed/33095810 http://dx.doi.org/10.1371/journal.pone.0241003 Text en © 2020 Okano et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Okano, Takahiro
Motoki, Hirohiko
Minamisawa, Masatoshi
Kimura, Kazuhiro
Kanai, Masafumi
Yoshie, Koji
Higuchi, Satoko
Saigusa, Tatsuya
Ebisawa, Soichiro
Okada, Ayako
Shoda, Morio
Kuwahara, Koichiro
Cardio-renal and cardio-hepatic interactions predict cardiovascular events in elderly patients with heart failure
title Cardio-renal and cardio-hepatic interactions predict cardiovascular events in elderly patients with heart failure
title_full Cardio-renal and cardio-hepatic interactions predict cardiovascular events in elderly patients with heart failure
title_fullStr Cardio-renal and cardio-hepatic interactions predict cardiovascular events in elderly patients with heart failure
title_full_unstemmed Cardio-renal and cardio-hepatic interactions predict cardiovascular events in elderly patients with heart failure
title_short Cardio-renal and cardio-hepatic interactions predict cardiovascular events in elderly patients with heart failure
title_sort cardio-renal and cardio-hepatic interactions predict cardiovascular events in elderly patients with heart failure
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584193/
https://www.ncbi.nlm.nih.gov/pubmed/33095810
http://dx.doi.org/10.1371/journal.pone.0241003
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