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Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report
Thyrotoxic periodic paralysis is a clinical condition characterized by muscle weakness in patients with underlying hyperthyroidism. It is usually more commonly seen in patients of Asian origin and has a predisposition for the male population (unlike other thyroid disorders which commonly affect the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584299/ https://www.ncbi.nlm.nih.gov/pubmed/33123447 http://dx.doi.org/10.7759/cureus.10634 |
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author | Iqbal, Qasim Z Zia, Zeeshan Niazi, Muhammad Sattar, Saud Bin Abdul Quyyumi, Shahed |
author_facet | Iqbal, Qasim Z Zia, Zeeshan Niazi, Muhammad Sattar, Saud Bin Abdul Quyyumi, Shahed |
author_sort | Iqbal, Qasim Z |
collection | PubMed |
description | Thyrotoxic periodic paralysis is a clinical condition characterized by muscle weakness in patients with underlying hyperthyroidism. It is usually more commonly seen in patients of Asian origin and has a predisposition for the male population (unlike other thyroid disorders which commonly affect the female population). Findings are more overt in patients who have subclinical hyperthyroidism and there is a risk of them remaining untreated. The symptoms can range from mild muscle weakness to total paralysis. The muscles affected predominantly are the proximal and lower extremities group of muscles. Thyrotoxic muscle paralysis can be precipitated by hyperinsulinemic states such as after heavy meals, physical exertion, obesity, stress, and certain medications like high-dose steroids, antiretrovirals, and interferon therapy. The acute intervention usually revolves around the replenishment of patient's potassium stores followed by maintenance therapy with anti-thyroid medications. We present a case of a Chinese adolescent who presented to us with lower muscle weakness and underlying subclinical hyperthyroidism. It's important for clinicians to be familiar with this disease entity and include it in their differentials whenever a patient with muscle weakness presents. The treatment is simple and can result in rapid improvement of symptoms and should be initiated quickly. |
format | Online Article Text |
id | pubmed-7584299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-75842992020-10-28 Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report Iqbal, Qasim Z Zia, Zeeshan Niazi, Muhammad Sattar, Saud Bin Abdul Quyyumi, Shahed Cureus Endocrinology/Diabetes/Metabolism Thyrotoxic periodic paralysis is a clinical condition characterized by muscle weakness in patients with underlying hyperthyroidism. It is usually more commonly seen in patients of Asian origin and has a predisposition for the male population (unlike other thyroid disorders which commonly affect the female population). Findings are more overt in patients who have subclinical hyperthyroidism and there is a risk of them remaining untreated. The symptoms can range from mild muscle weakness to total paralysis. The muscles affected predominantly are the proximal and lower extremities group of muscles. Thyrotoxic muscle paralysis can be precipitated by hyperinsulinemic states such as after heavy meals, physical exertion, obesity, stress, and certain medications like high-dose steroids, antiretrovirals, and interferon therapy. The acute intervention usually revolves around the replenishment of patient's potassium stores followed by maintenance therapy with anti-thyroid medications. We present a case of a Chinese adolescent who presented to us with lower muscle weakness and underlying subclinical hyperthyroidism. It's important for clinicians to be familiar with this disease entity and include it in their differentials whenever a patient with muscle weakness presents. The treatment is simple and can result in rapid improvement of symptoms and should be initiated quickly. Cureus 2020-09-24 /pmc/articles/PMC7584299/ /pubmed/33123447 http://dx.doi.org/10.7759/cureus.10634 Text en Copyright © 2020, Iqbal et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Endocrinology/Diabetes/Metabolism Iqbal, Qasim Z Zia, Zeeshan Niazi, Muhammad Sattar, Saud Bin Abdul Quyyumi, Shahed Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report |
title | Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report |
title_full | Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report |
title_fullStr | Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report |
title_full_unstemmed | Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report |
title_short | Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report |
title_sort | thyrotoxic muscle paralysis as a rare cause of reversible muscle weakness: a case report |
topic | Endocrinology/Diabetes/Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584299/ https://www.ncbi.nlm.nih.gov/pubmed/33123447 http://dx.doi.org/10.7759/cureus.10634 |
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