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Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report

Thyrotoxic periodic paralysis is a clinical condition characterized by muscle weakness in patients with underlying hyperthyroidism. It is usually more commonly seen in patients of Asian origin and has a predisposition for the male population (unlike other thyroid disorders which commonly affect the...

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Autores principales: Iqbal, Qasim Z, Zia, Zeeshan, Niazi, Muhammad, Sattar, Saud Bin Abdul, Quyyumi, Shahed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584299/
https://www.ncbi.nlm.nih.gov/pubmed/33123447
http://dx.doi.org/10.7759/cureus.10634
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author Iqbal, Qasim Z
Zia, Zeeshan
Niazi, Muhammad
Sattar, Saud Bin Abdul
Quyyumi, Shahed
author_facet Iqbal, Qasim Z
Zia, Zeeshan
Niazi, Muhammad
Sattar, Saud Bin Abdul
Quyyumi, Shahed
author_sort Iqbal, Qasim Z
collection PubMed
description Thyrotoxic periodic paralysis is a clinical condition characterized by muscle weakness in patients with underlying hyperthyroidism. It is usually more commonly seen in patients of Asian origin and has a predisposition for the male population (unlike other thyroid disorders which commonly affect the female population). Findings are more overt in patients who have subclinical hyperthyroidism and there is a risk of them remaining untreated. The symptoms can range from mild muscle weakness to total paralysis. The muscles affected predominantly are the proximal and lower extremities group of muscles. Thyrotoxic muscle paralysis can be precipitated by hyperinsulinemic states such as after heavy meals, physical exertion, obesity, stress, and certain medications like high-dose steroids, antiretrovirals, and interferon therapy. The acute intervention usually revolves around the replenishment of patient's potassium stores followed by maintenance therapy with anti-thyroid medications. We present a case of a Chinese adolescent who presented to us with lower muscle weakness and underlying subclinical hyperthyroidism. It's important for clinicians to be familiar with this disease entity and include it in their differentials whenever a patient with muscle weakness presents. The treatment is simple and can result in rapid improvement of symptoms and should be initiated quickly.
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spelling pubmed-75842992020-10-28 Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report Iqbal, Qasim Z Zia, Zeeshan Niazi, Muhammad Sattar, Saud Bin Abdul Quyyumi, Shahed Cureus Endocrinology/Diabetes/Metabolism Thyrotoxic periodic paralysis is a clinical condition characterized by muscle weakness in patients with underlying hyperthyroidism. It is usually more commonly seen in patients of Asian origin and has a predisposition for the male population (unlike other thyroid disorders which commonly affect the female population). Findings are more overt in patients who have subclinical hyperthyroidism and there is a risk of them remaining untreated. The symptoms can range from mild muscle weakness to total paralysis. The muscles affected predominantly are the proximal and lower extremities group of muscles. Thyrotoxic muscle paralysis can be precipitated by hyperinsulinemic states such as after heavy meals, physical exertion, obesity, stress, and certain medications like high-dose steroids, antiretrovirals, and interferon therapy. The acute intervention usually revolves around the replenishment of patient's potassium stores followed by maintenance therapy with anti-thyroid medications. We present a case of a Chinese adolescent who presented to us with lower muscle weakness and underlying subclinical hyperthyroidism. It's important for clinicians to be familiar with this disease entity and include it in their differentials whenever a patient with muscle weakness presents. The treatment is simple and can result in rapid improvement of symptoms and should be initiated quickly. Cureus 2020-09-24 /pmc/articles/PMC7584299/ /pubmed/33123447 http://dx.doi.org/10.7759/cureus.10634 Text en Copyright © 2020, Iqbal et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Iqbal, Qasim Z
Zia, Zeeshan
Niazi, Muhammad
Sattar, Saud Bin Abdul
Quyyumi, Shahed
Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report
title Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report
title_full Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report
title_fullStr Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report
title_full_unstemmed Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report
title_short Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report
title_sort thyrotoxic muscle paralysis as a rare cause of reversible muscle weakness: a case report
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584299/
https://www.ncbi.nlm.nih.gov/pubmed/33123447
http://dx.doi.org/10.7759/cureus.10634
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