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Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin

[Image: see text] A pathological signature of Alzheimer’s disease (AD) is the formation of neurofibrillary tangles comprising filamentous aggregates of the microtubule associated protein tau. Tau self-assembly is accelerated by polyanions including heparin, an analogue of heparan sulfate. Tau filame...

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Detalles Bibliográficos
Autores principales:	Townsend, David, Fullwood, Nigel J., Yates, Edwin A., Middleton, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584336/ https://www.ncbi.nlm.nih.gov/pubmed/32954725 http://dx.doi.org/10.1021/acs.biochem.0c00443

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