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Nano-targeting lessons from the SARS-CoV-2

The lack of targeting efficacy has frequently led functionalized nanoparticles to accumulate in unwanted cells and tissues while boosting toxicity-related effects. Conversely, viruses are natural nanoparticles that precisely and responsively interact with the biological machinery through an effectiv...

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Detalles Bibliográficos
Autores principales: Ribeiro, I.R.S., da Silva, R.F., Silveira, C.P., Galdino, F.E., Cardoso, M.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584425/
https://www.ncbi.nlm.nih.gov/pubmed/33139972
http://dx.doi.org/10.1016/j.nantod.2020.101012
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author Ribeiro, I.R.S.
da Silva, R.F.
Silveira, C.P.
Galdino, F.E.
Cardoso, M.B.
author_facet Ribeiro, I.R.S.
da Silva, R.F.
Silveira, C.P.
Galdino, F.E.
Cardoso, M.B.
author_sort Ribeiro, I.R.S.
collection PubMed
description The lack of targeting efficacy has frequently led functionalized nanoparticles to accumulate in unwanted cells and tissues while boosting toxicity-related effects. Conversely, viruses are natural nanoparticles that precisely and responsively interact with the biological machinery through an effective-driven fashion. This interaction is enhanced by a meticulous spatial arrangement which results in a quasi-crystalline distribution of proteins on the viruses’ surface. Amidst the COVID-19 pandemic, we propose to look at the SARS-CoV-2 nanoscale viral scaffold as an example of a highly-ordered architecture that must inspire and tailor the production of targeted synthetic nanoparticles.
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spelling pubmed-75844252020-10-26 Nano-targeting lessons from the SARS-CoV-2 Ribeiro, I.R.S. da Silva, R.F. Silveira, C.P. Galdino, F.E. Cardoso, M.B. Nano Today Opinion The lack of targeting efficacy has frequently led functionalized nanoparticles to accumulate in unwanted cells and tissues while boosting toxicity-related effects. Conversely, viruses are natural nanoparticles that precisely and responsively interact with the biological machinery through an effective-driven fashion. This interaction is enhanced by a meticulous spatial arrangement which results in a quasi-crystalline distribution of proteins on the viruses’ surface. Amidst the COVID-19 pandemic, we propose to look at the SARS-CoV-2 nanoscale viral scaffold as an example of a highly-ordered architecture that must inspire and tailor the production of targeted synthetic nanoparticles. Elsevier Ltd. 2021-02 2020-10-23 /pmc/articles/PMC7584425/ /pubmed/33139972 http://dx.doi.org/10.1016/j.nantod.2020.101012 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Opinion
Ribeiro, I.R.S.
da Silva, R.F.
Silveira, C.P.
Galdino, F.E.
Cardoso, M.B.
Nano-targeting lessons from the SARS-CoV-2
title Nano-targeting lessons from the SARS-CoV-2
title_full Nano-targeting lessons from the SARS-CoV-2
title_fullStr Nano-targeting lessons from the SARS-CoV-2
title_full_unstemmed Nano-targeting lessons from the SARS-CoV-2
title_short Nano-targeting lessons from the SARS-CoV-2
title_sort nano-targeting lessons from the sars-cov-2
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584425/
https://www.ncbi.nlm.nih.gov/pubmed/33139972
http://dx.doi.org/10.1016/j.nantod.2020.101012
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