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Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study

INTRODUCTION: Our understanding of risk factors for COVID‑19, including pre-existing medical conditions and genetic variations, is limited. To what extent the pre-existing clinical condition and genetic background have implications for COVID-19 still needs to be explored. METHODS: Our study included...

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Autores principales: Zhou, Jingqi, Liu, Chang, Sun, Yitang, Huang, Weishan, Ye, Kaixiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584518/
https://www.ncbi.nlm.nih.gov/pubmed/33148439
http://dx.doi.org/10.1016/j.bbi.2020.10.019
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author Zhou, Jingqi
Liu, Chang
Sun, Yitang
Huang, Weishan
Ye, Kaixiong
author_facet Zhou, Jingqi
Liu, Chang
Sun, Yitang
Huang, Weishan
Ye, Kaixiong
author_sort Zhou, Jingqi
collection PubMed
description INTRODUCTION: Our understanding of risk factors for COVID‑19, including pre-existing medical conditions and genetic variations, is limited. To what extent the pre-existing clinical condition and genetic background have implications for COVID-19 still needs to be explored. METHODS: Our study included 389,620 participants of European descent from the UK Biobank, of whom 3,884 received the COVID-19 test and 1,091 were tested positive for COVID-19. We examined the association of COVID-19 status with an extensive list of 974 medical conditions and 30 blood biomarkers. Additionally, we tested the association of genetic variants in two key genes related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2), with COVID-19 or any other phenotypes. RESULTS: The most significant risk factors for COVID-19 include Alzheimer’s disease (OR = 2.29, 95% CI: 1.25–4.16), dementia (OR = 2.16, 95% CI: 1.36–3.42), and the overall category of delirium, dementia, amnestic and other cognitive disorders (OR = 1.90, 95% CI: 1.24–2.90). Evidence suggesting associations of genetic variants in SARS-CoV-2 infection-related genes with COVID-19 (rs7282236, OR = 1.33, 95% CI: 1.14–1.54, p = 2.31 × 10(−4)) and other phenotypes, such as an immune deficiency (p = 5.65 × 10(−5)) and prostate cancer (p = 1.1 × 10(−5)), was obtained. CONCLUSIONS: Our unbiased and extensive search identified pre-existing Alzheimer’s disease and dementia as top risk factors for hospital admission due to COVID-19, highlighting the importance of providing special protective care for patients with cognitive disorders during this pandemic. We also obtained evidence suggesting a direct association of genetic variants with COVID-19.
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spelling pubmed-75845182020-10-26 Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study Zhou, Jingqi Liu, Chang Sun, Yitang Huang, Weishan Ye, Kaixiong Brain Behav Immun Article INTRODUCTION: Our understanding of risk factors for COVID‑19, including pre-existing medical conditions and genetic variations, is limited. To what extent the pre-existing clinical condition and genetic background have implications for COVID-19 still needs to be explored. METHODS: Our study included 389,620 participants of European descent from the UK Biobank, of whom 3,884 received the COVID-19 test and 1,091 were tested positive for COVID-19. We examined the association of COVID-19 status with an extensive list of 974 medical conditions and 30 blood biomarkers. Additionally, we tested the association of genetic variants in two key genes related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2), with COVID-19 or any other phenotypes. RESULTS: The most significant risk factors for COVID-19 include Alzheimer’s disease (OR = 2.29, 95% CI: 1.25–4.16), dementia (OR = 2.16, 95% CI: 1.36–3.42), and the overall category of delirium, dementia, amnestic and other cognitive disorders (OR = 1.90, 95% CI: 1.24–2.90). Evidence suggesting associations of genetic variants in SARS-CoV-2 infection-related genes with COVID-19 (rs7282236, OR = 1.33, 95% CI: 1.14–1.54, p = 2.31 × 10(−4)) and other phenotypes, such as an immune deficiency (p = 5.65 × 10(−5)) and prostate cancer (p = 1.1 × 10(−5)), was obtained. CONCLUSIONS: Our unbiased and extensive search identified pre-existing Alzheimer’s disease and dementia as top risk factors for hospital admission due to COVID-19, highlighting the importance of providing special protective care for patients with cognitive disorders during this pandemic. We also obtained evidence suggesting a direct association of genetic variants with COVID-19. The Author(s). Published by Elsevier Inc. 2021-01 2020-10-24 /pmc/articles/PMC7584518/ /pubmed/33148439 http://dx.doi.org/10.1016/j.bbi.2020.10.019 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zhou, Jingqi
Liu, Chang
Sun, Yitang
Huang, Weishan
Ye, Kaixiong
Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study
title Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study
title_full Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study
title_fullStr Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study
title_full_unstemmed Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study
title_short Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study
title_sort cognitive disorders associated with hospitalization of covid-19: results from an observational cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584518/
https://www.ncbi.nlm.nih.gov/pubmed/33148439
http://dx.doi.org/10.1016/j.bbi.2020.10.019
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