Cargando…

Exogenous L-arginine increases intestinal stem cell function through CD90+ stromal cells producing mTORC1-induced Wnt2b

The renewal and repair of intestinal epithelium depend on the self-renewal of intestinal stem cells (ISCs) under physiological and pathological conditions. Although previous work has established that exogenous nutrients regulate adult stem cell activity, little is known about the regulatory effect o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hou, Qihang, Dong, Yuanyang, Huang, Jingxi, Liao, Chaoyong, Lei, Jiaqi, Wang, Youli, Lai, Yujiao, Bian, Yifei, He, Yang, Sun, Jingjing, Sun, Meng, Jiang, Qiuyu, Wang, Bo, Yu, Zhengquan, Guo, Yuming, Zhang, Bingkun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584578/ https://www.ncbi.nlm.nih.gov/pubmed/33097830 http://dx.doi.org/10.1038/s42003-020-01347-9

Ejemplares similares

Intestinal Microbiota Regulate Certain Meat Quality Parameters in Chicken
por: Lei, Jiaqi, et al.
Publicado: (2022)

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
por: Saxton, Robert A., et al.
Publicado: (2016)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

NRF3 activates mTORC1 arginine-dependently for cancer cell viability
por: Hirose, Shuuhei, et al.
Publicado: (2023)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
por: Carroll, Bernadette, et al.
Publicado: (2016)

Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway
por: Gai, Zhongchao, et al.
Publicado: (2016)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Targeted Isolation of Antioxidant Constituents from Plantago asiatica L. and In Vitro Activity Assay
por: Dong, Yuanyang, et al.
Publicado: (2020)

Correction: Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
por: Carroll, Bernadette, et al.
Publicado: (2020)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

c-FLIP links mTORC2 to apoptosis
por: Zhao, Liqun, et al.
Publicado: (2014)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling
por: Xia, Jing, et al.
Publicado: (2016)

Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1
por: Buel, Gwen R., et al.
Publicado: (2022)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

Regulation of mTORC2 Signaling
por: Fu, Wenxiang, et al.
Publicado: (2020)

mTORC2 Steals the Spotlight
por: Jansen, Laura A.
Publicado: (2020)

Something to mTORC About in NASH
por: Finck, Brian N.
Publicado: (2022)

Quercetin Alleviates Intestinal Oxidative Damage Induced by H(2)O(2) via Modulation of GSH: In Vitro Screening and In Vivo Evaluation in a Colitis Model of Mice
por: Dong, Yuanyang, et al.
Publicado: (2020)

mTORC2: a multifaceted regulator of autophagy
por: Sun, Yanan, et al.
Publicado: (2023)

Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation
por: Yang, Fuchun, et al.
Publicado: (2020)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
por: Feldman, Morris E, et al.
Publicado: (2009)

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication
por: Kuss-Duerkop, Sharon K., et al.
Publicado: (2017)

Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization
por: Baek, Mi-Ock, et al.
Publicado: (2018)

Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
por: McCabe, Matthew P, et al.
Publicado: (2020)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

Hyperactivity of mTORC1 or mTORC2-dependent signaling causes epilepsy downstream of somatic PTEN loss
por: Cullen, Erin R., et al.
Publicado: (2023)

RIOK3 promotes mTORC1 activation by facilitating SLC7A2-mediated arginine uptake in pancreatic ductal adenocarcinoma
por: Qin, Henan, et al.
Publicado: (2023)

Effects of Bacillus subtilis Natto NB205 and Its Mutant NBMK308 on Egg Quality in Aging Laying Hens
por: Liao, Chaoyong, et al.
Publicado: (2023)

An expanded role for mTORC1 in autophagy
por: Kim, Young-Mi, et al.
Publicado: (2015)

mTORC1 as the main gateway to autophagy
por: Rabanal-Ruiz, Yoana, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_1hd7b6n70bh15d4cmjtlg8jn13