Genome-scale metabolic rewiring improves titers rates and yields of the non-native product indigoidine at scale

High titer, rate, yield (TRY), and scalability are challenging metrics to achieve due to trade-offs between carbon use for growth and production. To achieve these metrics, we take the minimal cut set (MCS) approach that predicts metabolic reactions for elimination to couple metabolite production str...

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Detalles Bibliográficos
Autores principales: Banerjee, Deepanwita, Eng, Thomas, Lau, Andrew K., Sasaki, Yusuke, Wang, Brenda, Chen, Yan, Prahl, Jan-Philip, Singan, Vasanth R., Herbert, Robin A., Liu, Yuzhong, Tanjore, Deepti, Petzold, Christopher J., Keasling, Jay D., Mukhopadhyay, Aindrila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584609/
https://www.ncbi.nlm.nih.gov/pubmed/33097726
http://dx.doi.org/10.1038/s41467-020-19171-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584609/
https://www.ncbi.nlm.nih.gov/pubmed/33097726
http://dx.doi.org/10.1038/s41467-020-19171-4

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