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Genome-scale metabolic rewiring improves titers rates and yields of the non-native product indigoidine at scale
High titer, rate, yield (TRY), and scalability are challenging metrics to achieve due to trade-offs between carbon use for growth and production. To achieve these metrics, we take the minimal cut set (MCS) approach that predicts metabolic reactions for elimination to couple metabolite production str...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584609/ https://www.ncbi.nlm.nih.gov/pubmed/33097726 http://dx.doi.org/10.1038/s41467-020-19171-4 |