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Systematic investigation of promoter substitutions resulting from somatic intrachromosomal structural alterations in diverse human cancers
One of the ways in which genes can become activated in tumors is by somatic structural genomic rearrangements leading to promoter swapping events, typically in the context of gene fusions that cause a weak promoter to be substituted for a strong promoter. While identifiable by whole genome sequencin...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584658/ https://www.ncbi.nlm.nih.gov/pubmed/33097743 http://dx.doi.org/10.1038/s41598-020-74420-2 |