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Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems
BACKGROUND: Microscopic patches as quite promising platforms in transdermal drug delivery suffer from conventional injections. In other hand, a wide range of pharmacokinetics, ranging from fast oral administration to sustained drug delivery, can be implemented with the help of microneedle arrays (MN...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584683/ https://www.ncbi.nlm.nih.gov/pubmed/33133689 http://dx.doi.org/10.1016/j.jare.2020.07.017 |
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author | Meng, Fansu Hasan, Anwarul Mahdi Nejadi Babadaei, Mohammad Hashemi Kani, Pegah Jouya Talaei, Amir Sharifi, Majid Cai, Tiange Falahati, Mojtaba Cai, Yu |
author_facet | Meng, Fansu Hasan, Anwarul Mahdi Nejadi Babadaei, Mohammad Hashemi Kani, Pegah Jouya Talaei, Amir Sharifi, Majid Cai, Tiange Falahati, Mojtaba Cai, Yu |
author_sort | Meng, Fansu |
collection | PubMed |
description | BACKGROUND: Microscopic patches as quite promising platforms in transdermal drug delivery suffer from conventional injections. In other hand, a wide range of pharmacokinetics, ranging from fast oral administration to sustained drug delivery, can be implemented with the help of microneedle arrays (MNAs). AIM OF REVIEW: Hence, in this paper, we overviewed different kinds of MNAs such as solid/coated, hollow, porous, hydrogel/swellable, and merged-tip geometry followed by introducing different types of material (silicon, glass, ceramics, dissolving and biodegradable polymers, and hydrogel) used for fabrication of MNAs. Afterwards, some conventional and brand-new simple and customizable MN mold fabrication techniques were surveyed. Polymeric MNAs have received a great deal of attention due to their potential biocompatibility and biodegradability in comparison to other materials. Therefore, we also covered different kinds of polymers such as hydrogel/swellable, dissolving and biodegradable analogues used for the development of MNAs as potential candidates in drug delivery systems (DDSs). Finally, we discussed different challenges and future perspectives in the aspect of MNAs-based drug delivery platforms. KEY SCIENTIFIC CONCEPTS OF REVIEW: This review may provide guidelines for the rational design of polymeric MNAs-based DDSs for promising programmable drug release and enhanced therapeutic effect. |
format | Online Article Text |
id | pubmed-7584683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-75846832020-10-30 Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems Meng, Fansu Hasan, Anwarul Mahdi Nejadi Babadaei, Mohammad Hashemi Kani, Pegah Jouya Talaei, Amir Sharifi, Majid Cai, Tiange Falahati, Mojtaba Cai, Yu J Adv Res Article BACKGROUND: Microscopic patches as quite promising platforms in transdermal drug delivery suffer from conventional injections. In other hand, a wide range of pharmacokinetics, ranging from fast oral administration to sustained drug delivery, can be implemented with the help of microneedle arrays (MNAs). AIM OF REVIEW: Hence, in this paper, we overviewed different kinds of MNAs such as solid/coated, hollow, porous, hydrogel/swellable, and merged-tip geometry followed by introducing different types of material (silicon, glass, ceramics, dissolving and biodegradable polymers, and hydrogel) used for fabrication of MNAs. Afterwards, some conventional and brand-new simple and customizable MN mold fabrication techniques were surveyed. Polymeric MNAs have received a great deal of attention due to their potential biocompatibility and biodegradability in comparison to other materials. Therefore, we also covered different kinds of polymers such as hydrogel/swellable, dissolving and biodegradable analogues used for the development of MNAs as potential candidates in drug delivery systems (DDSs). Finally, we discussed different challenges and future perspectives in the aspect of MNAs-based drug delivery platforms. KEY SCIENTIFIC CONCEPTS OF REVIEW: This review may provide guidelines for the rational design of polymeric MNAs-based DDSs for promising programmable drug release and enhanced therapeutic effect. Elsevier 2020-08-01 /pmc/articles/PMC7584683/ /pubmed/33133689 http://dx.doi.org/10.1016/j.jare.2020.07.017 Text en © 2020 The Authors. Published by Elsevier B.V. on behalf of Cairo University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Meng, Fansu Hasan, Anwarul Mahdi Nejadi Babadaei, Mohammad Hashemi Kani, Pegah Jouya Talaei, Amir Sharifi, Majid Cai, Tiange Falahati, Mojtaba Cai, Yu Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems |
title | Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems |
title_full | Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems |
title_fullStr | Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems |
title_full_unstemmed | Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems |
title_short | Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems |
title_sort | polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584683/ https://www.ncbi.nlm.nih.gov/pubmed/33133689 http://dx.doi.org/10.1016/j.jare.2020.07.017 |
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