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Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems

BACKGROUND: Microscopic patches as quite promising platforms in transdermal drug delivery suffer from conventional injections. In other hand, a wide range of pharmacokinetics, ranging from fast oral administration to sustained drug delivery, can be implemented with the help of microneedle arrays (MN...

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Autores principales: Meng, Fansu, Hasan, Anwarul, Mahdi Nejadi Babadaei, Mohammad, Hashemi Kani, Pegah, Jouya Talaei, Amir, Sharifi, Majid, Cai, Tiange, Falahati, Mojtaba, Cai, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584683/
https://www.ncbi.nlm.nih.gov/pubmed/33133689
http://dx.doi.org/10.1016/j.jare.2020.07.017
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author Meng, Fansu
Hasan, Anwarul
Mahdi Nejadi Babadaei, Mohammad
Hashemi Kani, Pegah
Jouya Talaei, Amir
Sharifi, Majid
Cai, Tiange
Falahati, Mojtaba
Cai, Yu
author_facet Meng, Fansu
Hasan, Anwarul
Mahdi Nejadi Babadaei, Mohammad
Hashemi Kani, Pegah
Jouya Talaei, Amir
Sharifi, Majid
Cai, Tiange
Falahati, Mojtaba
Cai, Yu
author_sort Meng, Fansu
collection PubMed
description BACKGROUND: Microscopic patches as quite promising platforms in transdermal drug delivery suffer from conventional injections. In other hand, a wide range of pharmacokinetics, ranging from fast oral administration to sustained drug delivery, can be implemented with the help of microneedle arrays (MNAs). AIM OF REVIEW: Hence, in this paper, we overviewed different kinds of MNAs such as solid/coated, hollow, porous, hydrogel/swellable, and merged-tip geometry followed by introducing different types of material (silicon, glass, ceramics, dissolving and biodegradable polymers, and hydrogel) used for fabrication of MNAs. Afterwards, some conventional and brand-new simple and customizable MN mold fabrication techniques were surveyed. Polymeric MNAs have received a great deal of attention due to their potential biocompatibility and biodegradability in comparison to other materials. Therefore, we also covered different kinds of polymers such as hydrogel/swellable, dissolving and biodegradable analogues used for the development of MNAs as potential candidates in drug delivery systems (DDSs). Finally, we discussed different challenges and future perspectives in the aspect of MNAs-based drug delivery platforms. KEY SCIENTIFIC CONCEPTS OF REVIEW: This review may provide guidelines for the rational design of polymeric MNAs-based DDSs for promising programmable drug release and enhanced therapeutic effect.
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spelling pubmed-75846832020-10-30 Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems Meng, Fansu Hasan, Anwarul Mahdi Nejadi Babadaei, Mohammad Hashemi Kani, Pegah Jouya Talaei, Amir Sharifi, Majid Cai, Tiange Falahati, Mojtaba Cai, Yu J Adv Res Article BACKGROUND: Microscopic patches as quite promising platforms in transdermal drug delivery suffer from conventional injections. In other hand, a wide range of pharmacokinetics, ranging from fast oral administration to sustained drug delivery, can be implemented with the help of microneedle arrays (MNAs). AIM OF REVIEW: Hence, in this paper, we overviewed different kinds of MNAs such as solid/coated, hollow, porous, hydrogel/swellable, and merged-tip geometry followed by introducing different types of material (silicon, glass, ceramics, dissolving and biodegradable polymers, and hydrogel) used for fabrication of MNAs. Afterwards, some conventional and brand-new simple and customizable MN mold fabrication techniques were surveyed. Polymeric MNAs have received a great deal of attention due to their potential biocompatibility and biodegradability in comparison to other materials. Therefore, we also covered different kinds of polymers such as hydrogel/swellable, dissolving and biodegradable analogues used for the development of MNAs as potential candidates in drug delivery systems (DDSs). Finally, we discussed different challenges and future perspectives in the aspect of MNAs-based drug delivery platforms. KEY SCIENTIFIC CONCEPTS OF REVIEW: This review may provide guidelines for the rational design of polymeric MNAs-based DDSs for promising programmable drug release and enhanced therapeutic effect. Elsevier 2020-08-01 /pmc/articles/PMC7584683/ /pubmed/33133689 http://dx.doi.org/10.1016/j.jare.2020.07.017 Text en © 2020 The Authors. Published by Elsevier B.V. on behalf of Cairo University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Meng, Fansu
Hasan, Anwarul
Mahdi Nejadi Babadaei, Mohammad
Hashemi Kani, Pegah
Jouya Talaei, Amir
Sharifi, Majid
Cai, Tiange
Falahati, Mojtaba
Cai, Yu
Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems
title Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems
title_full Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems
title_fullStr Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems
title_full_unstemmed Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems
title_short Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems
title_sort polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584683/
https://www.ncbi.nlm.nih.gov/pubmed/33133689
http://dx.doi.org/10.1016/j.jare.2020.07.017
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