Cargando…

An updated meta-analysis of the association between fibroblast growth factor receptor 4 polymorphisms and susceptibility to cancer

Fibroblast growth factor receptor 4 (FGFR4) is a cell surface receptor tyrosine kinases (RTKs) for FGFs. Several studies have focused on the association between FGFR4 polymorphisms and cancer development. This meta-analysis aimed to estimate the association between FGFR4 rs351855 (Gly(388)Arg), rs19...

Descripción completa

Detalles Bibliográficos
Autores principales: Moazeni-Roodi, Abdolkarim, Sarabandi, Sahel, Karami, Shima, Hashemi, Mohammad, Ghavami, Saeid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584815/
https://www.ncbi.nlm.nih.gov/pubmed/33017009
http://dx.doi.org/10.1042/BSR20192051
_version_ 1783599663258009600
author Moazeni-Roodi, Abdolkarim
Sarabandi, Sahel
Karami, Shima
Hashemi, Mohammad
Ghavami, Saeid
author_facet Moazeni-Roodi, Abdolkarim
Sarabandi, Sahel
Karami, Shima
Hashemi, Mohammad
Ghavami, Saeid
author_sort Moazeni-Roodi, Abdolkarim
collection PubMed
description Fibroblast growth factor receptor 4 (FGFR4) is a cell surface receptor tyrosine kinases (RTKs) for FGFs. Several studies have focused on the association between FGFR4 polymorphisms and cancer development. This meta-analysis aimed to estimate the association between FGFR4 rs351855 (Gly(388)Arg), rs1966265 (Val(10)Ile), rs7708357, rs2011077, and rs376618 polymorphisms and cancer risk. Eligible studies were identified from electronic databases. All statistical analyses were achieved with the STATA 14.0 software. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to quantitatively estimate the association. Overall, no significant association was found among rs351855, rs2011077, and rs376618 polymorphisms with the risk of overall cancer. The rs1966265 polymorphism significantly decreased the risk of cancer in recessive (OR = 0.87, 95% CI = 0.78–0.97, P=0.009, TT vs CT+CC) genetic model. Whereas the rs7708357 polymorphism was positively associated with cancer risk in dominant (OR = 1.17, 95% CI = 1.02–1.36, P=0.028) genetic model. Stratified analysis revealed that rs351855 variant significantly increased the risk of prostate cancer in heterozygous (OR = 1.16, 95% CI = 1.02–1.32, P=0.025 AG vs GG), dominant (OR = 1.20, 95% CI = 1.06–1.35, P=0.004, AG+AA vs GG), and allele (OR = 1.22, 95% CI = 1.06–1.41, P=0.005, A vs G) genetic models. In summary, the findings of this meta-analysis indicate that rs1966265, rs7708357, and rs351855 polymorphisms are correlated to cancer development. Further well-designed studies are necessary to draw more precise conclusions.
format Online
Article
Text
id pubmed-7584815
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-75848152020-10-28 An updated meta-analysis of the association between fibroblast growth factor receptor 4 polymorphisms and susceptibility to cancer Moazeni-Roodi, Abdolkarim Sarabandi, Sahel Karami, Shima Hashemi, Mohammad Ghavami, Saeid Biosci Rep Cancer Fibroblast growth factor receptor 4 (FGFR4) is a cell surface receptor tyrosine kinases (RTKs) for FGFs. Several studies have focused on the association between FGFR4 polymorphisms and cancer development. This meta-analysis aimed to estimate the association between FGFR4 rs351855 (Gly(388)Arg), rs1966265 (Val(10)Ile), rs7708357, rs2011077, and rs376618 polymorphisms and cancer risk. Eligible studies were identified from electronic databases. All statistical analyses were achieved with the STATA 14.0 software. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to quantitatively estimate the association. Overall, no significant association was found among rs351855, rs2011077, and rs376618 polymorphisms with the risk of overall cancer. The rs1966265 polymorphism significantly decreased the risk of cancer in recessive (OR = 0.87, 95% CI = 0.78–0.97, P=0.009, TT vs CT+CC) genetic model. Whereas the rs7708357 polymorphism was positively associated with cancer risk in dominant (OR = 1.17, 95% CI = 1.02–1.36, P=0.028) genetic model. Stratified analysis revealed that rs351855 variant significantly increased the risk of prostate cancer in heterozygous (OR = 1.16, 95% CI = 1.02–1.32, P=0.025 AG vs GG), dominant (OR = 1.20, 95% CI = 1.06–1.35, P=0.004, AG+AA vs GG), and allele (OR = 1.22, 95% CI = 1.06–1.41, P=0.005, A vs G) genetic models. In summary, the findings of this meta-analysis indicate that rs1966265, rs7708357, and rs351855 polymorphisms are correlated to cancer development. Further well-designed studies are necessary to draw more precise conclusions. Portland Press Ltd. 2020-10-23 /pmc/articles/PMC7584815/ /pubmed/33017009 http://dx.doi.org/10.1042/BSR20192051 Text en © 2020 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
spellingShingle Cancer
Moazeni-Roodi, Abdolkarim
Sarabandi, Sahel
Karami, Shima
Hashemi, Mohammad
Ghavami, Saeid
An updated meta-analysis of the association between fibroblast growth factor receptor 4 polymorphisms and susceptibility to cancer
title An updated meta-analysis of the association between fibroblast growth factor receptor 4 polymorphisms and susceptibility to cancer
title_full An updated meta-analysis of the association between fibroblast growth factor receptor 4 polymorphisms and susceptibility to cancer
title_fullStr An updated meta-analysis of the association between fibroblast growth factor receptor 4 polymorphisms and susceptibility to cancer
title_full_unstemmed An updated meta-analysis of the association between fibroblast growth factor receptor 4 polymorphisms and susceptibility to cancer
title_short An updated meta-analysis of the association between fibroblast growth factor receptor 4 polymorphisms and susceptibility to cancer
title_sort updated meta-analysis of the association between fibroblast growth factor receptor 4 polymorphisms and susceptibility to cancer
topic Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584815/
https://www.ncbi.nlm.nih.gov/pubmed/33017009
http://dx.doi.org/10.1042/BSR20192051
work_keys_str_mv AT moazeniroodiabdolkarim anupdatedmetaanalysisoftheassociationbetweenfibroblastgrowthfactorreceptor4polymorphismsandsusceptibilitytocancer
AT sarabandisahel anupdatedmetaanalysisoftheassociationbetweenfibroblastgrowthfactorreceptor4polymorphismsandsusceptibilitytocancer
AT karamishima anupdatedmetaanalysisoftheassociationbetweenfibroblastgrowthfactorreceptor4polymorphismsandsusceptibilitytocancer
AT hashemimohammad anupdatedmetaanalysisoftheassociationbetweenfibroblastgrowthfactorreceptor4polymorphismsandsusceptibilitytocancer
AT ghavamisaeid anupdatedmetaanalysisoftheassociationbetweenfibroblastgrowthfactorreceptor4polymorphismsandsusceptibilitytocancer
AT moazeniroodiabdolkarim updatedmetaanalysisoftheassociationbetweenfibroblastgrowthfactorreceptor4polymorphismsandsusceptibilitytocancer
AT sarabandisahel updatedmetaanalysisoftheassociationbetweenfibroblastgrowthfactorreceptor4polymorphismsandsusceptibilitytocancer
AT karamishima updatedmetaanalysisoftheassociationbetweenfibroblastgrowthfactorreceptor4polymorphismsandsusceptibilitytocancer
AT hashemimohammad updatedmetaanalysisoftheassociationbetweenfibroblastgrowthfactorreceptor4polymorphismsandsusceptibilitytocancer
AT ghavamisaeid updatedmetaanalysisoftheassociationbetweenfibroblastgrowthfactorreceptor4polymorphismsandsusceptibilitytocancer