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Bardoxolone Methyl Displays Detrimental Effects on Endothelial Bioenergetics, Suppresses Endothelial ET-1 Release, and Increases Endothelial Permeability in Human Microvascular Endothelium

Nrf2 is a master regulator of antioxidant cellular defence, and agents activating the Nrf2 pathway have been tested in various diseases. However, unexpected side effects of cardiovascular nature reported for bardoxolone methyl in patients with type 2 diabetes mellitus and stage 4 chronic kidney dise...

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Detalles Bibliográficos
Autores principales:	Szczesny-Malysiak, Ewa, Stojak, Marta, Campagna, Roberto, Grosicki, Marek, Jamrozik, Marek, Kaczara, Patrycja, Chlopicki, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584962/ https://www.ncbi.nlm.nih.gov/pubmed/33123312 http://dx.doi.org/10.1155/2020/4678252

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