Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca(2+) signals that are inhibited by oncogenic KRas

Changes in the mechanical microenvironment and mechanical signals are observed during tumor progression, malignant transformation, and metastasis. In this context, understanding the molecular details of mechanotransduction signaling may provide unique therapeutic targets. Here, we report that normal...

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Detalles Bibliográficos
Autores principales: Pratt, Stephen J. P., Lee, Rachel M., Chang, Katarina T., Hernández-Ochoa, Erick O., Annis, David A., Ory, Eleanor C., Thompson, Keyata N., Bailey, Patrick C., Mathias, Trevor J., Ju, Julia A., Vitolo, Michele I., Schneider, Martin F., Stains, Joseph P., Ward, Christopher W., Martin, Stuart S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7584994/
https://www.ncbi.nlm.nih.gov/pubmed/33020304
http://dx.doi.org/10.1073/pnas.2009495117

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