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SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime
Pneumonia outbreak in the city of Wuhan, China, prompted the finding of a novel strain of severe acute respiratory syndrome virus (SARS-CoV-2). Here, we discuss potential long-term consequences of SARS-CoV-2 infection, and its possibility to cause permanent damage to the immune system and the centra...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585069/ https://www.ncbi.nlm.nih.gov/pubmed/32991323 http://dx.doi.org/10.18632/aging.103989 |
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author | Domingues, Renato Lippi, Alice Setz, Cristian Outeiro, Tiago F. Krisko, Anita |
author_facet | Domingues, Renato Lippi, Alice Setz, Cristian Outeiro, Tiago F. Krisko, Anita |
author_sort | Domingues, Renato |
collection | PubMed |
description | Pneumonia outbreak in the city of Wuhan, China, prompted the finding of a novel strain of severe acute respiratory syndrome virus (SARS-CoV-2). Here, we discuss potential long-term consequences of SARS-CoV-2 infection, and its possibility to cause permanent damage to the immune system and the central nervous system. Advanced chronological age is one of the main risk factors for the adverse outcomes of COVID-19, presumably due to immunosenescence and chronic low-grade inflammation, both characteristic of the elderly. The combination of viral infection and chronic inflammation in advanced chronological age might cause multiple detrimental unforeseen consequences for the predisposition and severity of neurodegenerative diseases and needs to be considered so that we can be prepared to deal with future outcomes of the ongoing pandemic. |
format | Online Article Text |
id | pubmed-7585069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-75850692020-11-03 SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime Domingues, Renato Lippi, Alice Setz, Cristian Outeiro, Tiago F. Krisko, Anita Aging (Albany NY) Review Pneumonia outbreak in the city of Wuhan, China, prompted the finding of a novel strain of severe acute respiratory syndrome virus (SARS-CoV-2). Here, we discuss potential long-term consequences of SARS-CoV-2 infection, and its possibility to cause permanent damage to the immune system and the central nervous system. Advanced chronological age is one of the main risk factors for the adverse outcomes of COVID-19, presumably due to immunosenescence and chronic low-grade inflammation, both characteristic of the elderly. The combination of viral infection and chronic inflammation in advanced chronological age might cause multiple detrimental unforeseen consequences for the predisposition and severity of neurodegenerative diseases and needs to be considered so that we can be prepared to deal with future outcomes of the ongoing pandemic. Impact Journals 2020-09-29 /pmc/articles/PMC7585069/ /pubmed/32991323 http://dx.doi.org/10.18632/aging.103989 Text en Copyright: © 2020 Domingues et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Domingues, Renato Lippi, Alice Setz, Cristian Outeiro, Tiago F. Krisko, Anita SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime |
title | SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime |
title_full | SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime |
title_fullStr | SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime |
title_full_unstemmed | SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime |
title_short | SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime |
title_sort | sars-cov-2, immunosenescence and inflammaging: partners in the covid-19 crime |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585069/ https://www.ncbi.nlm.nih.gov/pubmed/32991323 http://dx.doi.org/10.18632/aging.103989 |
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