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circKIF4A sponges miR-127 to promote ovarian cancer progression

Ovarian cancer is a major gynecologic cancer and common cause of gynecologic cancer death worldwide. However, the molecular mechanisms of ovarian cancer progression are still unclear. circular RNAs (circRNAs) are recently reported to be involved in cancer progression regulation but the potential fun...

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Autores principales: Sheng, Shunliang, Hu, Yi, Yu, Furong, Tong, Wenjuan, Wang, Shufen, Cai, Yanlin, Zhu, Jiayu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585112/
https://www.ncbi.nlm.nih.gov/pubmed/32979257
http://dx.doi.org/10.18632/aging.103389
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author Sheng, Shunliang
Hu, Yi
Yu, Furong
Tong, Wenjuan
Wang, Shufen
Cai, Yanlin
Zhu, Jiayu
author_facet Sheng, Shunliang
Hu, Yi
Yu, Furong
Tong, Wenjuan
Wang, Shufen
Cai, Yanlin
Zhu, Jiayu
author_sort Sheng, Shunliang
collection PubMed
description Ovarian cancer is a major gynecologic cancer and common cause of gynecologic cancer death worldwide. However, the molecular mechanisms of ovarian cancer progression are still unclear. circular RNAs (circRNAs) are recently reported to be involved in cancer progression regulation but the potential functions of circRNAs in ovarian cancer remains unknown. In this study, we explored the expression of circKIF4A in ovarian cancer tissues. Then, a series of experiments were conducted to investigate how circKIF4A functioned in ovarian cancer in vitro and in vivo. The results revealed that circKIF4A was highly expressed in ovarian cancer tissues. Knockdown of circKIF4A suppressed cell proliferation and migration in ovarian cancer. Subsequent mechanism study revealed that circKIF4A acted as a competitive endogenous RNA (ceRNA) to promoted ovarian cancer progression by sponging miR-127 and upregulated the expression of Junctional adhesion molecule 3 (JAM3). Therefore, circKIF4A could be a novel biomarker and therapeutic target for ovarian cancer.
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spelling pubmed-75851122020-11-03 circKIF4A sponges miR-127 to promote ovarian cancer progression Sheng, Shunliang Hu, Yi Yu, Furong Tong, Wenjuan Wang, Shufen Cai, Yanlin Zhu, Jiayu Aging (Albany NY) Research Paper Ovarian cancer is a major gynecologic cancer and common cause of gynecologic cancer death worldwide. However, the molecular mechanisms of ovarian cancer progression are still unclear. circular RNAs (circRNAs) are recently reported to be involved in cancer progression regulation but the potential functions of circRNAs in ovarian cancer remains unknown. In this study, we explored the expression of circKIF4A in ovarian cancer tissues. Then, a series of experiments were conducted to investigate how circKIF4A functioned in ovarian cancer in vitro and in vivo. The results revealed that circKIF4A was highly expressed in ovarian cancer tissues. Knockdown of circKIF4A suppressed cell proliferation and migration in ovarian cancer. Subsequent mechanism study revealed that circKIF4A acted as a competitive endogenous RNA (ceRNA) to promoted ovarian cancer progression by sponging miR-127 and upregulated the expression of Junctional adhesion molecule 3 (JAM3). Therefore, circKIF4A could be a novel biomarker and therapeutic target for ovarian cancer. Impact Journals 2020-08-05 /pmc/articles/PMC7585112/ /pubmed/32979257 http://dx.doi.org/10.18632/aging.103389 Text en Copyright: © 2020 Sheng et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Sheng, Shunliang
Hu, Yi
Yu, Furong
Tong, Wenjuan
Wang, Shufen
Cai, Yanlin
Zhu, Jiayu
circKIF4A sponges miR-127 to promote ovarian cancer progression
title circKIF4A sponges miR-127 to promote ovarian cancer progression
title_full circKIF4A sponges miR-127 to promote ovarian cancer progression
title_fullStr circKIF4A sponges miR-127 to promote ovarian cancer progression
title_full_unstemmed circKIF4A sponges miR-127 to promote ovarian cancer progression
title_short circKIF4A sponges miR-127 to promote ovarian cancer progression
title_sort circkif4a sponges mir-127 to promote ovarian cancer progression
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585112/
https://www.ncbi.nlm.nih.gov/pubmed/32979257
http://dx.doi.org/10.18632/aging.103389
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