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Hypertension is associated with reduced hippocampal connectivity and impaired memory()
BACKGROUND: The objective was a large-scale analysis of the relation between hypertension, memory problems, and brain function. METHODS: The study design was to measure the association between a history of hypertension, and the functional connectivity between 94 brain regions, and prospective and nu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585137/ https://www.ncbi.nlm.nih.gov/pubmed/33132184 http://dx.doi.org/10.1016/j.ebiom.2020.103082 |
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author | Feng, Ruiqing Rolls, Edmund T Cheng, Wei Feng, Jianfeng |
author_facet | Feng, Ruiqing Rolls, Edmund T Cheng, Wei Feng, Jianfeng |
author_sort | Feng, Ruiqing |
collection | PubMed |
description | BACKGROUND: The objective was a large-scale analysis of the relation between hypertension, memory problems, and brain function. METHODS: The study design was to measure the association between a history of hypertension, and the functional connectivity between 94 brain regions, and prospective and numeric memory, in 19,507 participants from the UK Biobank, with cross-validation in 1,002 participants in the Human Connectome Project, and 13,441 individuals in the second release of the UK Biobank. A history of hypertension was measured by whether individuals were admitted to hospital for the treatment of hypertension, with the control group admissions for other reasons. FINDINGS: A history of hypertension was associated with reduced functional connectivity of the hippocampus, and with reduced prospective memory score (FDR correction p<0.01). The reduced functional connectivity mediated the association between the hypertension history and the prospective memory score. A graded linear relation between both the hippocampal functional connectivity and memory impairment, was found across a wide range of blood pressure (r=-0.04). In 502,537 participants from the UK Biobank, a history of hypertension was associated with impaired prospective memory (p = 9.1 × 10(−41), Cohen's d=-0.08) and numeric memory (p = 4.7 × 10(−24), Cohen's d=-0.10). The association between hypertension, functional connectivity, and impaired memory was cross-validated with 1,002 participants from the Human Connectome Project; and for functional connectivity in 13,441 individuals in the second release of the UK Biobank imaging dataset. INTERPRETATION: The reduced functional connectivity of the hippocampus, and the memory impairments, both related to hypertension across a wide range of blood pressure, are important for clinical practice. |
format | Online Article Text |
id | pubmed-7585137 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-75851372020-10-30 Hypertension is associated with reduced hippocampal connectivity and impaired memory() Feng, Ruiqing Rolls, Edmund T Cheng, Wei Feng, Jianfeng EBioMedicine Research paper BACKGROUND: The objective was a large-scale analysis of the relation between hypertension, memory problems, and brain function. METHODS: The study design was to measure the association between a history of hypertension, and the functional connectivity between 94 brain regions, and prospective and numeric memory, in 19,507 participants from the UK Biobank, with cross-validation in 1,002 participants in the Human Connectome Project, and 13,441 individuals in the second release of the UK Biobank. A history of hypertension was measured by whether individuals were admitted to hospital for the treatment of hypertension, with the control group admissions for other reasons. FINDINGS: A history of hypertension was associated with reduced functional connectivity of the hippocampus, and with reduced prospective memory score (FDR correction p<0.01). The reduced functional connectivity mediated the association between the hypertension history and the prospective memory score. A graded linear relation between both the hippocampal functional connectivity and memory impairment, was found across a wide range of blood pressure (r=-0.04). In 502,537 participants from the UK Biobank, a history of hypertension was associated with impaired prospective memory (p = 9.1 × 10(−41), Cohen's d=-0.08) and numeric memory (p = 4.7 × 10(−24), Cohen's d=-0.10). The association between hypertension, functional connectivity, and impaired memory was cross-validated with 1,002 participants from the Human Connectome Project; and for functional connectivity in 13,441 individuals in the second release of the UK Biobank imaging dataset. INTERPRETATION: The reduced functional connectivity of the hippocampus, and the memory impairments, both related to hypertension across a wide range of blood pressure, are important for clinical practice. Elsevier 2020-10-22 /pmc/articles/PMC7585137/ /pubmed/33132184 http://dx.doi.org/10.1016/j.ebiom.2020.103082 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research paper Feng, Ruiqing Rolls, Edmund T Cheng, Wei Feng, Jianfeng Hypertension is associated with reduced hippocampal connectivity and impaired memory() |
title | Hypertension is associated with reduced hippocampal connectivity and impaired memory() |
title_full | Hypertension is associated with reduced hippocampal connectivity and impaired memory() |
title_fullStr | Hypertension is associated with reduced hippocampal connectivity and impaired memory() |
title_full_unstemmed | Hypertension is associated with reduced hippocampal connectivity and impaired memory() |
title_short | Hypertension is associated with reduced hippocampal connectivity and impaired memory() |
title_sort | hypertension is associated with reduced hippocampal connectivity and impaired memory() |
topic | Research paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585137/ https://www.ncbi.nlm.nih.gov/pubmed/33132184 http://dx.doi.org/10.1016/j.ebiom.2020.103082 |
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