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Enhanced efficacy of JAK1 inhibitor with mTORC1/C2 targeting in smoldering/chronic adult T cell leukemia

Adult T-cell leukemia (ATL) is an aggressive T-cell lymphoproliferative malignancy of regulatory T lymphocytes (Tregs), caused by human T-cell lymphotropic virus 1 (HTLV-1). Interleukin 2 receptor alpha (IL-2Rα) is expressed in the leukemic cells of smoldering/chronic ATL patients, leading to consti...

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Detalles Bibliográficos
Autores principales:	Daenthanasanmak, Anusara, Lin, Yuquan, Zhang, Meili, Bryant, Bonita R., Petrus, Michael N., Bamford, Richard N., Thomas, Craig J., Miljkovic, Milos D., Conlon, Kevin C., Waldmann, Thomas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2020
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585144/ https://www.ncbi.nlm.nih.gov/pubmed/33129109 http://dx.doi.org/10.1016/j.tranon.2020.100913

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