Cargando…

Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer

MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast ca...

Descripción completa

Detalles Bibliográficos
Autores principales: NGUYEN, Thanh Thi Ngoc, TRAN, Minh Thi Hong, NGUYEN, Vy Thi Lan, NGUYEN, Uyen Doan Phuong, NGUYEN, Giang Dien Thanh, HUYNH, Luan Huu, NGUYEN, Hue Thi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585164/
https://www.ncbi.nlm.nih.gov/pubmed/33110366
http://dx.doi.org/10.3906/biy-2004-78
_version_ 1783599728494116864
author NGUYEN, Thanh Thi Ngoc
TRAN, Minh Thi Hong
NGUYEN, Vy Thi Lan
NGUYEN, Uyen Doan Phuong
NGUYEN, Giang Dien Thanh
HUYNH, Luan Huu
NGUYEN, Hue Thi
author_facet NGUYEN, Thanh Thi Ngoc
TRAN, Minh Thi Hong
NGUYEN, Vy Thi Lan
NGUYEN, Uyen Doan Phuong
NGUYEN, Giang Dien Thanh
HUYNH, Luan Huu
NGUYEN, Hue Thi
author_sort NGUYEN, Thanh Thi Ngoc
collection PubMed
description MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer (BC). Ongoing investigations in malignant growth diagnostics have distinguished miRNAs as promising disease biomarkers. As with any other mRNAs, single nucleotide polymorphisms (SNPs) in DNA sequence encoding for miRNA (miR-SNPs) indeed lead to potential changes in the function of miRNA. In this study, miR-SNPs located in different miRNA sequence regions, which have been associated with BC in different ways, and the potential mechanisms of how these miR-SNPs develop the risk of the disease were discussed.
format Online
Article
Text
id pubmed-7585164
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Scientific and Technological Research Council of Turkey
record_format MEDLINE/PubMed
spelling pubmed-75851642020-10-26 Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer NGUYEN, Thanh Thi Ngoc TRAN, Minh Thi Hong NGUYEN, Vy Thi Lan NGUYEN, Uyen Doan Phuong NGUYEN, Giang Dien Thanh HUYNH, Luan Huu NGUYEN, Hue Thi Turk J Biol Article MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer (BC). Ongoing investigations in malignant growth diagnostics have distinguished miRNAs as promising disease biomarkers. As with any other mRNAs, single nucleotide polymorphisms (SNPs) in DNA sequence encoding for miRNA (miR-SNPs) indeed lead to potential changes in the function of miRNA. In this study, miR-SNPs located in different miRNA sequence regions, which have been associated with BC in different ways, and the potential mechanisms of how these miR-SNPs develop the risk of the disease were discussed. The Scientific and Technological Research Council of Turkey 2020-10-13 /pmc/articles/PMC7585164/ /pubmed/33110366 http://dx.doi.org/10.3906/biy-2004-78 Text en Copyright © 2020 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Article
NGUYEN, Thanh Thi Ngoc
TRAN, Minh Thi Hong
NGUYEN, Vy Thi Lan
NGUYEN, Uyen Doan Phuong
NGUYEN, Giang Dien Thanh
HUYNH, Luan Huu
NGUYEN, Hue Thi
Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer
title Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer
title_full Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer
title_fullStr Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer
title_full_unstemmed Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer
title_short Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer
title_sort single nucleotide polymorphisms in micrornas action as biomarkers for breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585164/
https://www.ncbi.nlm.nih.gov/pubmed/33110366
http://dx.doi.org/10.3906/biy-2004-78
work_keys_str_mv AT nguyenthanhthingoc singlenucleotidepolymorphismsinmicrornasactionasbiomarkersforbreastcancer
AT tranminhthihong singlenucleotidepolymorphismsinmicrornasactionasbiomarkersforbreastcancer
AT nguyenvythilan singlenucleotidepolymorphismsinmicrornasactionasbiomarkersforbreastcancer
AT nguyenuyendoanphuong singlenucleotidepolymorphismsinmicrornasactionasbiomarkersforbreastcancer
AT nguyengiangdienthanh singlenucleotidepolymorphismsinmicrornasactionasbiomarkersforbreastcancer
AT huynhluanhuu singlenucleotidepolymorphismsinmicrornasactionasbiomarkersforbreastcancer
AT nguyenhuethi singlenucleotidepolymorphismsinmicrornasactionasbiomarkersforbreastcancer