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No Significant Effect of Daikenchuto (TJ-100) on Peritoneal IL-9 and IFN-γ Levels After Pancreaticoduodenectomy
AIM AND BACKGROUND: TJ-100 is a traditional Japanese medicine that affects inflammation and gastrointestinal motility, and is used as a preventive and treatment for paralytic ileus. This study aims at determining the effect of TJ-100 on the peritoneal levels of IFN-γ/IL-9, cytokines related to ileus...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585168/ https://www.ncbi.nlm.nih.gov/pubmed/33116743 http://dx.doi.org/10.2147/CEG.S262082 |
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author | Maeda, Hiromichi Okada, Ken-ichi Fujii, Tsutomu Oba, Mari S Kawai, Manabu Hirono, Seiko Kodera, Yasuhiro Sho, Masayuki Akahori, Takahiro Shimizu, Yasuhiro Ambo, Yoshiyasu Kondo, Naru Murakami, Yoshiaki Ohuchida, Jiro Eguchi, Hidetoshi Nagano, Hiroaki Sakamoto, Junichi Yamaue, Hiroki |
author_facet | Maeda, Hiromichi Okada, Ken-ichi Fujii, Tsutomu Oba, Mari S Kawai, Manabu Hirono, Seiko Kodera, Yasuhiro Sho, Masayuki Akahori, Takahiro Shimizu, Yasuhiro Ambo, Yoshiyasu Kondo, Naru Murakami, Yoshiaki Ohuchida, Jiro Eguchi, Hidetoshi Nagano, Hiroaki Sakamoto, Junichi Yamaue, Hiroki |
author_sort | Maeda, Hiromichi |
collection | PubMed |
description | AIM AND BACKGROUND: TJ-100 is a traditional Japanese medicine that affects inflammation and gastrointestinal motility, and is used as a preventive and treatment for paralytic ileus. This study aims at determining the effect of TJ-100 on the peritoneal levels of IFN-γ/IL-9, cytokines related to ileus, after pancreaticoduodenectomy (PD) in a clinical setting. METHODS: This was a subsidiary study of the clinical trial investigating the effect of TJ-100 on postoperative bowel function. Ascites was collected from 180 patients using an abdominal drainage tube on postoperative day 1 and 3 after PD (POD 1 or POD 3) and used to measure 27 cytokines. We performed univariate and multivariate analyses using several perioperative variables and administration of TJ-100/placebo to determine the effect of TJ-100 on the levels of IFN-γ and IL-9. RESULTS: Peritoneal levels of IL-9 and IFN-γ decreased between POD 1 and 3 (Wilcoxon signed-rank test p<0.001). Multivariate analysis was performed after univariate analysis to select the variables and patients with a body mass index of ≥22 kg/m(2), older age, use of epidural anesthesia, and longer surgery correlated with the levels of IL-9 and IFN-γ. However, we could not detect a correlation between the use of TJ-100 and cytokine levels in ascites either on POD 1 or 3. CONCLUSION: TJ-100 did not affect peritoneal IL-9 and IFN-γ levels after PD. This was in accordance with published clinical findings showing no improvement in bowel function after PD and TJ-100 treatment. |
format | Online Article Text |
id | pubmed-7585168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-75851682020-10-27 No Significant Effect of Daikenchuto (TJ-100) on Peritoneal IL-9 and IFN-γ Levels After Pancreaticoduodenectomy Maeda, Hiromichi Okada, Ken-ichi Fujii, Tsutomu Oba, Mari S Kawai, Manabu Hirono, Seiko Kodera, Yasuhiro Sho, Masayuki Akahori, Takahiro Shimizu, Yasuhiro Ambo, Yoshiyasu Kondo, Naru Murakami, Yoshiaki Ohuchida, Jiro Eguchi, Hidetoshi Nagano, Hiroaki Sakamoto, Junichi Yamaue, Hiroki Clin Exp Gastroenterol Original Research AIM AND BACKGROUND: TJ-100 is a traditional Japanese medicine that affects inflammation and gastrointestinal motility, and is used as a preventive and treatment for paralytic ileus. This study aims at determining the effect of TJ-100 on the peritoneal levels of IFN-γ/IL-9, cytokines related to ileus, after pancreaticoduodenectomy (PD) in a clinical setting. METHODS: This was a subsidiary study of the clinical trial investigating the effect of TJ-100 on postoperative bowel function. Ascites was collected from 180 patients using an abdominal drainage tube on postoperative day 1 and 3 after PD (POD 1 or POD 3) and used to measure 27 cytokines. We performed univariate and multivariate analyses using several perioperative variables and administration of TJ-100/placebo to determine the effect of TJ-100 on the levels of IFN-γ and IL-9. RESULTS: Peritoneal levels of IL-9 and IFN-γ decreased between POD 1 and 3 (Wilcoxon signed-rank test p<0.001). Multivariate analysis was performed after univariate analysis to select the variables and patients with a body mass index of ≥22 kg/m(2), older age, use of epidural anesthesia, and longer surgery correlated with the levels of IL-9 and IFN-γ. However, we could not detect a correlation between the use of TJ-100 and cytokine levels in ascites either on POD 1 or 3. CONCLUSION: TJ-100 did not affect peritoneal IL-9 and IFN-γ levels after PD. This was in accordance with published clinical findings showing no improvement in bowel function after PD and TJ-100 treatment. Dove 2020-10-19 /pmc/articles/PMC7585168/ /pubmed/33116743 http://dx.doi.org/10.2147/CEG.S262082 Text en © 2020 Maeda et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Maeda, Hiromichi Okada, Ken-ichi Fujii, Tsutomu Oba, Mari S Kawai, Manabu Hirono, Seiko Kodera, Yasuhiro Sho, Masayuki Akahori, Takahiro Shimizu, Yasuhiro Ambo, Yoshiyasu Kondo, Naru Murakami, Yoshiaki Ohuchida, Jiro Eguchi, Hidetoshi Nagano, Hiroaki Sakamoto, Junichi Yamaue, Hiroki No Significant Effect of Daikenchuto (TJ-100) on Peritoneal IL-9 and IFN-γ Levels After Pancreaticoduodenectomy |
title | No Significant Effect of Daikenchuto (TJ-100) on Peritoneal IL-9 and IFN-γ Levels After Pancreaticoduodenectomy |
title_full | No Significant Effect of Daikenchuto (TJ-100) on Peritoneal IL-9 and IFN-γ Levels After Pancreaticoduodenectomy |
title_fullStr | No Significant Effect of Daikenchuto (TJ-100) on Peritoneal IL-9 and IFN-γ Levels After Pancreaticoduodenectomy |
title_full_unstemmed | No Significant Effect of Daikenchuto (TJ-100) on Peritoneal IL-9 and IFN-γ Levels After Pancreaticoduodenectomy |
title_short | No Significant Effect of Daikenchuto (TJ-100) on Peritoneal IL-9 and IFN-γ Levels After Pancreaticoduodenectomy |
title_sort | no significant effect of daikenchuto (tj-100) on peritoneal il-9 and ifn-γ levels after pancreaticoduodenectomy |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585168/ https://www.ncbi.nlm.nih.gov/pubmed/33116743 http://dx.doi.org/10.2147/CEG.S262082 |
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